中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (2): 292-297.doi: 10.4103/1673-5374.152385

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

针刺正常人太冲、太溪穴哪些脑区能被激活或受抑制：的静息态fMRI脑功能成像验证

  

  • 收稿日期:2014-10-22 出版日期:2015-02-17 发布日期:2015-02-17
  • 基金资助:

    国家重点基础研究发展计划（973计划），批准号：2012cb518504；国家级大学生创新创业训练项目，201212121048号；和三级重点学科建设项目广东省（211项目），批准号：yuefagaishe（2009）431

Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging

Shao-qun Zhang 1, Yan-jie Wang 1, Ji-ping Zhang 1, Jun-qi Chen 1, Chun-xiao Wu 1, Zhi-peng Li 2, Jia-rong Chen 2, Huai-liang Ouyang 1, Yong Huang 1, Chun-zhi Tang 3
   

  1. 1 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
    2 First Clinical School, Southern Medical University, Guangzhou, Guangdong Province, China
    3 School of Acupuncture and Tuina, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
  • Received:2014-10-22 Online:2015-02-17 Published:2015-02-17
  • Contact: Yong Huang, M.D. or Chun-zhi Tang, M.D., nfhy@smu.edu.cn or jordan664@163.com.
  • Supported by:

    This study was supported by a grant from the National Key Basic Research and Development Project (973 Program), No. 2012CB518504; a grant from the National Level Undergraduate Student Innovation Venture Training Project of Local Colleges, No. 201212121048; and a grant from the Three-Stage Key Subject Construction Project of Guangdong Province of China (211 Project), No. (2009)431

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摘要：

目前研究已证明针灸能促使脑相关区域的变化。然而,大多数报告仅停留于对单个穴位的研究。文章基于静息态-功能性磁共振脑功能成像（fMRI）技术，观察针刺健康志愿者太冲太溪穴前后脑区的变化。纳入15例健康志愿者，针刺前15 min接受静息态全脑功能磁共振数据采集，继而采取爪切法针刺太冲穴和太溪穴（LR3，KI3），留针30 min，出针后15 min再次对健康志愿者进行全脑功能磁共振扫描。结果显示针刺健康志愿者太冲太溪穴后，引起低频振荡振幅升高的脑区均集中在大脑枕叶—枕中回（BA18/19），枕下回（BA18)和楔叶(BA18)，引起脑功能区低频振荡振幅降低的脑区主要集中在额叶—额叶直回(BA11)和额叶额下回（BA44）以及小脑后叶椎体。说明针刺健康志愿者太冲太溪穴能相对特异性促进与视觉、情感及认知有关脑区激活提高这些脑区的血流量，同时还能相对特异性的抑制与情绪、注意力、语音及语义处理、记忆等有关脑区激活，降低这些脑区的血流量。
 

关键词: 神经再生, 针刺, 神经影像学, 静息态, 功能性磁共振成像, 太冲, 太溪, 低频振荡振幅, 大脑布鲁德曼18区（BA18）, 大脑布鲁德曼11区（BA11）, 大脑布鲁德曼19区（BA19）, 大脑布鲁德曼44区（BA44）, ；小脑后叶椎体

Abstract:

Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture at Taichong (LR3) and Taixi (KI3) using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture at Taichong and Taixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic resonance imaging, which revealed that the amplitude of low-frequency fluctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus (Brodmann area 18/19), inferior occipital gyrus (Brodmann area 18) and cuneus (Brodmann area 18), but decreased mainly in the gyrus rectus of the frontal lobe (Brodmann area 11), inferior frontal gyrus (Brodmann area 44) and the center of the posterior lobe of the cerebellum. The present findings indicate that acupuncture at Taichong and Taixi specifically promote blood flow and activation in the brain areas related to vision, emotion and cognition, and inhibit brain areas related to emotion, attention, phonological and semantic processing, and memory.

Key words: nerve regeneration, acupuncture, neuroimaging, resting-state functional magnetic    , resonance imaging, Taichong (LR3), Taixi (KI3), amplitude of low-frequency fluctuation, Brodmann area 11, Brodmann area 18, Brodmann area 19, Brodmann area 44, posterior lobe of the cerebellum, neural regeneration