中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1825-1829.doi: 10.4103/1673-5374.170312

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

鞘内注射异丙酚对脊髓缺血的神经保护作用?

  

  • 收稿日期:2015-09-08 出版日期:2015-12-07 发布日期:2015-12-07

Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?

Murat Sahin1, *, Huriye Gullu2, Kemal Peker3, Ilyas Sayar4, Orhan Binici2, Huseyin Yildiz5   

  1. 1 Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Amasya, Amasya, Turkey
    2 Department of Anesthesiology and Reanimation, Mengucek Gazi Research and Training Hospital, Erzincan, Turkey
    3 Department of General Surgery, Faculty of Medicine, University of Erzincan, Erzincan, Turkey
    4 Department of Pathology, Faculty of Medicine, University of Erzincan, Erzincan, Turkey
    5 Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Sutcu Imam, Kahramanmaras,Turkey
  • Received:2015-09-08 Online:2015-12-07 Published:2015-12-07
  • Contact: Murat Sahin, M.D.,muratsahin4006@hotmail.com.

摘要:

异丙酚的神经保护效应已得到研究证实,但其脊髓鞘内给药是否有对脊髓缺血的预防性保护效应尚待验证。由此,实验于大鼠脊髓缺血性损伤前1h脊髓鞘内注射100和300 µg异丙酚,进行预处理。结果发现异丙酚预处理对大鼠脊髓缺血后24h的病理改变和神经功能缺损有明显的改善作用。说明脊髓鞘内注射异丙酚预处理可预防性保护脊髓缺血后结构和功能损害。

关键词: 神经再生, 异丙酚, 预处理, 脊髓, 缺血, 截瘫, 神经保护

Abstract:

The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 μg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia.

Key words: nerve regeneration, propofol, pre-treatment, spinal cord, ischemia, neuroprotection, paraplegia, neural regeneration