中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (4): 676-681.doi: 10.4103/1673-5374.180757

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

犬阴部神经电刺激可调控兴奋性阴部神经-膀胱反射

  

  • 收稿日期:2015-09-11 出版日期:2016-04-30 发布日期:2016-04-30
  • 基金资助:

    首都医学发展研究基金项目(2014-2-4141)

Electrical stimulation of dog pudendal nerve regulates the excitatory pudendal-to-bladder reflex

Yan-he Ju1, 2, Li-min Liao1, 2, *   

  1. 1 Department of Urology, China Rehabilitation Research Center, Beijing, China; School of Rahabilitation Medicine, Capital Medical University, Beijing, China
    2 Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
  • Received:2015-09-11 Online:2016-04-30 Published:2016-04-30
  • Contact: Li-min Liao, M.D., Ph.D., lmliao@263.net.
  • Supported by:

    This study was supported by the Capital Medical Development Research Fund of China, No. 2014-2-4141.

摘要:

阴部神经对膀胱储尿和排尿具有重要作用。因此认为骶髓损伤后将神经假体置于阴部神经干上可调节膀胱功能。我们既往研究已经证实刺激阴部神经干或神经分支抑制阴部神经-膀胱反射。实验以阴部神经干刺激引起脊髓未损伤或损伤犬膀胱兴奋性反应,得出的最佳刺激频率为15-25Hz,且这种兴奋性在一定程度上依赖于膀胱充盈体积。因此我们得出阴部神经干刺激是调节膀胱功能的一种有效的方法。

orcid: 0000-0002-7092-6576 (Li-min Liao)

关键词: 神经再生, 犬, 阴部神经, 神经性膀胱, 脊髓损伤, 电刺激, 尿动力学, 排尿反射, 神经调节

Abstract:

Pudendal nerve plays an important role in urine storage and voiding. Our hypothesis is that a neuroprosthetic device placed in the pudendal
nerve trunk can modulate bladder function after suprasacral spinal cord injury. We had confirmed the inhibitory pudendal-to-bladder
reflex by stimulating either the branch or the trunk of the pudendal nerve. This study explored the excitatory pudendal-to-bladder reflex
in beagle dogs, with intact or injured spinal cord, by electrical stimulation of the pudendal nerve trunk. The optimal stimulation frequency
was approximately 15–25 Hz. This excitatory effect was dependent to some extent on the bladder volume. We conclude that stimulation of
the pudendal nerve trunk is a promising method to modulate bladder function.

Key words: nerve regeneration, pudendal nerve, neurogenic bladder, spinal cord injury, electrical stimulation, urodynamics, voiding reflex, neuromodulation, neural regeneration