中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (9): 1424-1430.doi: 10.4103/1673-5374.191215

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

缺血性脑卒中患者局部脑结构异常：基于体素的形态学分析

  

  • 收稿日期:2016-08-17 出版日期:2016-09-30 发布日期:2016-09-30
  • 基金资助:
    973项目（2012CB518501）；中国国家自然科学基金项目（81072864）

Regional brain structural abnormality in ischemic stroke patients: a voxel-based morphometry study

Ping Wu1, #, Yu-mei Zhou1, #, Fang Zeng1, Zheng-jie Li1, Lu Luo2, Yong-xin Li3, Wei Fan1, Li-hua Qiu4, Wei Qin5, Lin Chen1, Lin Bai1, Juan Nie1, San Zhang1, Yan Xiong1, Yu Bai1, Can-xin Yin1, Fan-rong Liang1, *   

  1. 1 Acupuncture and Tuina School/Third Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China 2 China Academy of Chinese Medical Sciences, World Federation of Acupuncture-Moxibustion Societies, Beijing, China 3 Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China 4 Radiology Department, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China 5 Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, Shaanxi Province, China
  • Received:2016-08-17 Online:2016-09-30 Published:2016-09-30
  • Contact: Fan-rong Liang, acuresearch@126.com.
  • Supported by:
    This study was financially supported by the National Program on Key Basic Research Project of China (973 Program), No.2012CB518501; and the National Natural Science Foundation of China, No. 81072864.

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摘要：

作者既往曾采用局部一致性分析方法，发现缺血性脑卒中患者的某些脑区局部活性会发生明显改变。为准确性定缺血性脑卒中患者脑区的变化，作者对11例缺血性脑卒中患者以及15名健康受试者进行磁共振成像扫描后体素形态学分析，发现与健康人相比，脑卒中患者左侧中央前回、右侧小脑脚1区、右侧额中回及左侧颞中回灰质密度降低，而左侧枕下回与右侧前扣带回灰质密度增加，额中回的灰质密度变化与简易运动功能评定量表评分呈负相关(r = -0.737，P = 0.010)，颞中回灰质密度变化与神经功能缺损量表评分呈负相关(r = -0.609，P = 0.047)。作者认为，此结果可客观确认缺血性脑卒中患者局部脑结构出现异常变化。 orcid: 0000-0002-8598-3936 (Fan-rong Liang)

关键词: 神经再生, 缺血性脑卒中, 脑结构异常, 功能磁共振成像, 灰质密度, 基于体素的形态学分析, 简易运动功能评定量表, 神经功能缺损量表, 神经功能缺陷, 神经重组, 神经可塑性

Abstract: Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed signifcantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clinical rating scales of the Fugl-Meyer Motor Assessment (r = –0.609, P = 0.047) and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional defciency scale (r = –0.737, P = 0.010). Our fndings can objectively identify the functional abnormality in some brain regions of ischemic stroke patients.

Key words: nerve regeneration, ischemic stroke, brain structure abnormality, functional magnetic resonance imaging, gray matter density, voxel-based morphometry, Fugl-Meyer Motor Assessment, nervous functional deficiency scale, functional deficiency, neuroplasticity, neural reorganization, neural regeneration