中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (3): 492-496.doi: 10.4103/1673-5374.228733

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

缺血后处理对横断坐骨神经的神经保护

  

  • 收稿日期:2018-01-23 出版日期:2018-03-15 发布日期:2018-03-15
  • 基金资助:

    2016年北京市自然科学基金项目(71520061);北京市科委项目(Z161100000116080)

Neuroprotective effect of ischemic postconditioning on sciatic nerve transection

Xiao-bin Zhou1, 2, Na Liu3, Dong Wang1, De-xin Zou4, Chang-wei Wei5, Jun-lin Zhou1   

  1. 1 Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    2 Department of Traumatic Orthopedics, the Third Hospital of Shijiazhuang, Shijiazhuang, Hebei Province, China
    3 Department of Internal Neurology, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
    4 Department of Spine Surgery, Yan Tai-Shan Hospital, Yantai, Shandong Province, China
    5 Department of Anesthesia, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
  • Received:2018-01-23 Online:2018-03-15 Published:2018-03-15
  • Contact: Jun-lin Zhou, M.D.,junlinzhouvip@sina.com
  • Supported by:

    This work was supported by the 2016 Beijing Municipal Natural Science Foundation (CN), No. 71520061; Beijing Municipal Science and Technology Commission, China, No. Z161100000116080

摘要:

研究显示缺血预处理或后处理能够对脑缺血产生神经保护作用,但是还未见其对周围神经损伤保护的研究。因此实验设计构建坐骨神经横断损伤模型大鼠,其后每天对大鼠后肢进行3次每次10min缺血+10min再灌注处理,见坐骨神经损伤大鼠经缺血后处理后血清胰岛素样生长因子1表达增加,坐骨神经许旺细胞髓鞘化增加,感觉功能和运动功能明显恢复。此结果提示缺血后处理能有效保护损伤的坐骨神经,且其保护作用可能与胰岛素样生长因子1表达上调有关。

orcid:0000-0002-2988-663X(Jun-lin Zhou)

 

关键词: 神经再生, 缺血后处理, 神经损伤, 胰岛素样生长因子1, 坐骨神经, 缺血再灌注

Abstract:

Ischemic preconditioning or postconditioning has been shown to have neuroprotective effect on cerebral ischemia, but it has not been studied in peripheral nerve injury. In this study, a rat model of sciatic nerve transection was established, and subjected to three cycles of ischemia for 10 minutes + reperfusion for 10 minutes, once a day. After ischemic postconditioning, serum insulin-like growth factor 1 expression increased; sciatic nerve Schwann cell myelination increased; sensory function and motor function were restored. These findings indicate that ischemic postconditioning can effectively protect injured sciatic nerve. The protective effect is possibly associated with upregulation of insulin-like growth factor 1.

Key words: nerve regeneration, ischemic postconditioning, nerve injury, insulin-like growth factor 1, sciatic nerve, ischemia/reperfusion, neural regeneration