中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2025, Vol. 20 ›› Issue (10): 2787-2806.doi: 10.4103/NRR.NRR-D-24-00112

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤过程中的细胞焦亡及铁死亡和自噬：调控机制与治疗靶点

  

  • 出版日期:2025-10-15 发布日期:2025-02-07

Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets

Qingcong Zheng1, #, Du Wang2, #, Rongjie Lin3, #, Weihong Xu1, *   

  1. 1 Department of Spinal Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China;  2 Arthritis Clinical and Research Center, Peking University People’s Hospital, Beijing, China;  3 Department of Orthopedic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China
  • Online:2025-10-15 Published:2025-02-07
  • Contact: Weihong Xu, MD, xuweihong815@126.com.
  • Supported by:
    The work was supported by the Natural Science Foundation of Fujian Province, No. 2021J02035 (to WX).

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摘要：

调节性细胞死亡是一种由生物分子主动调节的细胞死亡形式。多项研究表明，调节性细胞死亡在脊髓损伤后起着重要的作用。细胞焦亡和铁死亡是近年来新发现的2种调节性细胞死亡类型，均会加剧炎症反应，并导致受损脊髓中细胞的死亡。而自噬是一种复杂的细胞死亡类型，可与多种调节性细胞死亡相互作用。脊髓损伤中的自噬引起了研究者的广泛兴趣，其不仅促进细胞死亡，而且能促进细胞的存活。此外，多种信号通路可通过调节细胞焦亡、铁死亡和自噬来影响脊髓损伤的恶化或修复过程。因此，此次综述总结了脊髓损伤中焦亡、铁死亡和自噬的作用机制、调控通路和治疗靶点等多方面的研究进展。调节调节性细胞死亡的共同信号调节通路，可促进脊髓细胞的存活和脊髓损伤的修复。此外，多种调节性细胞死亡结合多种调控途径的整体网络将是一种治疗脊髓损伤的潜在多靶点联合方案。

https://orcid.org/0000-0001-9490-8500 (Weihong Xu)

关键词: 脊髓损伤, 细胞死亡, 调节性细胞死亡, 焦亡, 铁死亡, 自噬, 炎症, 病理机制, 治疗靶点, 调节通路

Abstract: Regulated cell death is a form of cell death that is actively controlled by biomolecules. Several studies have shown that regulated cell death plays a key role after spinal cord injury. Pyroptosis and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal cords. Autophagy, a complex form of cell death that is interconnected with various regulated cell death mechanisms, has garnered significant attention in the study of spinal cord injury. This injury triggers not only cell death but also cellular survival responses. Multiple signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis, ferroptosis, and autophagy. Therefore, this review aims to comprehensively examine the mechanisms underlying regulated cell deaths, the signaling pathways that modulate these mechanisms, and the potential therapeutic targets for spinal cord injury. Our analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord injury. Moreover, a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

Key words: autophagy,  cell death,  ferroptosis,  inflammation,  pathological mechanisms,  pyroptosis,  regulated cell death,  regulatory pathways,  spinal cord injury,  therapeutic targets