中国神经再生研究(英文版) ›› 2021, Vol. 21 ›› Issue (5): 1723-1737.doi: 10.4103/NRR.NRR-D-24-01382

• 综述:退行性病与再生 • 上一篇    下一篇

铁稳态在神经退行性疾病中的作用

  

  • 出版日期:2026-05-15 发布日期:2025-08-20

The critical role of iron homeostasis in neurodegenerative diseases

Tiantian Liang1, 2, 3, 4, #, Jiasen Xu1, 2, 3, 4, #, Yan Zhu1, 2, 3, 4, #, He Zhao1, 2, 3, 4, Xiaoyu Zhai1, 2, 3, 4, Qi Wang1, 2, 3, 4, Xiaohui Ma1, 2, 3, 4, Limei Cui1, 2, 3, 4, *, Yan Sun1, 2, 3, 4, *   

  1. 1 Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China;  2 Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, Shandong, China;  3 Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, Shandong, China;  4 Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, Shandong, China
  • Online:2026-05-15 Published:2025-08-20
  • Contact: Yan Sun, MD, entsunyan@126.com; Limei Cui, PhD, icuili@126.com.
  • Supported by:

    1 Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China; 

    2 Shandong Provincial Key Laboratory of Neuroimmune Interaction and Regulation, Yantai, Shandong, China; 

    3 Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, Shandong, China; 

    4 Yantai Key Laboratory of Otorhinolaryngologic Diseases, Yantai, Shandong, China

摘要:

神经退行性疾病是严重影响人类健康的常见疾病。这些疾病的主要特征是神经元功能的逐渐丧失和最终死亡,尽管人们对这些过程的确切机制仍然知之甚少。铁是人体必需的微量元素,在各种生物过程中发挥着至关重要的作用。它对许多生命过程都是不可或缺的。铁平衡的维持依赖于人体复杂而微妙的调节机制。近年来,铁稳态失调与神经退行性疾病之间的关系备受关注。细胞内铁平衡的调节对于维持神经系统的正常功能至关重要。研究已经发现,铁稳态失调可能导致铁变态反应和氧化应激,进而影响神经元的健康并导致神经退行性疾病的发生。了解铁稳态与神经退行性疾病的关系对于揭示神经退行性疾病的发病机制和寻找新的治疗靶点具有重要意义。此综述主要讨论了铁稳态与阿尔茨海默病、帕金森病、弗里德里希共济失调、亨廷顿病、肌萎缩侧索硬化、多发性硬化等神经退行性疾病之间的关系。对铁稳态和神经退行性疾病作用的进一步研究有望为治疗和预防神经退行性疾病提供新的思路和方法。

https://orcid.org/0000-0003-3384-101X (Yan Sun); https://orcid.org/0000-0002-5767-9347 (Limei Cui)

关键词: 神经退行性疾病, 铁稳态, , 铁调节蛋白, 阿尔茨海默病, 帕金森病, 弗里德里希共济失调, 亨廷顿病, 肌萎缩侧索硬化, 多发性硬化

Abstract: Neurodegenerative diseases are prevalent conditions that greatly impact human health. These diseases are primarily characterized by the progressive loss and eventual death of neuronal function, although the precise mechanisms underlying these processes remain incompletely understood. Iron is an essential trace element in the human body, playing a crucial role in various biological processes. The maintenance of iron homeostasis relies on the body’s intricate and nuanced regulatory mechanisms. In recent years, considerable attention has been directed toward the relationship between dysregulated iron homeostasis and neurodegenerative diseases. The regulation of iron homeostasis within cells is crucial for maintaining proper nervous system function. Research has already revealed that disruptions in iron homeostasis may lead to ferroptosis and oxidative stress, which, in turn, can impact neuronal health and contribute to the development of neurodegenerative diseases. This article primarily explores the intimate relationship between iron homeostasis and neurodegenerative diseases, aiming to provide novel insights and strategies for treating these debilitating conditions.

Key words: ferroprotein, neurodegenerative diseases, iron homeostasis, iron, iron regulatory proteins