中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (12): 2141-2146.doi: 10.4103/1673-5374.241465

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

大脑白质高信号发生率随年龄增长而增加

  

  • 收稿日期:2018-05-28 出版日期:2018-12-15 发布日期:2018-12-15
  • 基金资助:

    湖北省自然科学基金项目（2015CFB260），湖北省卫计委科研项目（WJ2015MB219）

Prevalence of white matter hyperintensities increases with age

Feng-Juan Zhuang1, Yan Chen1, Wen-Bo He1, Zhi-You Cai2   

  1. 1 Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China
    2 Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China
  • Received:2018-05-28 Online:2018-12-15 Published:2018-12-15
  • Contact: Zhi-You Cai, MD, PhD, czy000806@163.com.
  • Supported by:

    This study was supported by the Natural Science Foundation of Hubei Province of China, No. 2015CFB260; the Health and Family Planning Scientific Research Project of Hubei Province of China, No. WJ2015MB219 (to WBH and ZYC).

PDF

257

摘要：

由年龄和动脉粥样硬化引起的大脑白质高信号是发生在脑白质中的一种异质性疾病，然而年龄相关危险因素与大脑白质高信号发生率的关系尚不明确。为探索年龄与大脑白质高信号发生之间的关系，我们对于在湖北医药学院附属人民医院2015年1月至2016年2月进行治疗的836例患者进行回顾性病例对照研究，根据T2-MRI结果将患者分为大脑白质高信号组(n=333)和非大脑白质高信号组(n=503)。其中大脑白质高信号组中男159例，女174例。分析结果显示，大脑白质高信号的发生率随着年龄的增长而增加，且其Fazekas量表评分评价得出的大脑白质高信号的体积负荷也随年龄的增长而增加。大脑白质高信号的发生率与年龄相关的危险因素，如心血管疾病、吸烟、饮酒、糖尿病、高血压和脑梗死史有关，且性别、文化程度、高脂血症和高同型半胱氨酸血症的差异对大脑白质高信号的发生没有影响。说明年龄是大脑白质高信号发生和严重程度的独立危险因素，与年龄有关的风险因素能增加大脑白质高信号的发生。

orcid:0000-0002-9552-4020(Zhi-You Cai)

 

关键词: 大脑白质, 发病率, 严重程度, 年龄, 风险因素, 回顾性分析, 脑血管

Abstract:

White matter hyperintensities (WMHs) that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the relationship between age and the prevalence of WMHs. We collected 836 patients, who were treated in the Renmin Hospital, Hubei University of Medicine, China from January 2015 to February 2016, for a case-controlled retrospective analysis. According to T2-weighted magnetic resonance imaging results, all patients were divided into a WMHs group (n = 333) and a non-WMHs group (n = 503). The WMHs group contained 159 males and 174 females. The prevalence of WMHs increased with age and was associated with age-related risk factors, such as cardiovascular diseases, smoking, drinking, diabetes, hypertension and history of cerebral infarction. There was no significant difference in sex, education level, hyperlipidemia and hyperhomocysteinemia among the different age ranges. These findings confirm that age is an independent risk factor for the prevalence and severity of WMHs. The age-related risk factors enhance the occurrence of WMHs.

Key words: nerve regeneration, white matter, prevalence, severity, age, risk factor, retrospective analysis, cerebrovascular, neural regeneration