中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2018, Vol. 13 ›› Issue (2): 304-308.doi: 10.4103/1673-5374.213555

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

异常脑电图对脑梗死后抑郁的预测能力

  

  • 收稿日期:2017-06-12 出版日期:2018-02-15 发布日期:2018-02-15
  • 基金资助:

    中国国家自然科学基金项目（81372919），广东省自然科学基金项目（2014A030313016），深圳市基础重点研究项目基金（JCYJ20150324140036853），深圳市科技项目基金（JCYJ20140418181958477）

Predictive power of abnormal electroencephalogram for post-cerebral infarction depression

Yan-ping Zheng1, Fu-xi Wang2, De-qiang Zhao3, Yan-qing Wang4, Zi-wei Zhao1, Zhan-wen Wang1, Jun Liu5, Jun Wang1, Ping Luan1, 6   

  1. 1 Health Science Center, Shenzhen University, Shenzhen, Guangdong Province, China
    2 Department of Dermatology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong Province, China
    3 Department of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
    4 Department of Neurology, Shenzhen Second People’s Hospital, Shenzhen, Guangdong Province, China
    5 Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China
    6 Cognitive Impairment Ward, Department of Neurology, Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, China
  • Received:2017-06-12 Online:2018-02-15 Published:2018-02-15
  • Contact: Ping Luan, M.D. or Jun Wang,M.D., pingluan01@163.com or yxywj@szu.edu.cn.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81372919; the Natural Science Foundation of Guangdong Province of China, No. 2014A030313016; the Basic Key Research Project Fund of Shenzhen City of China, No.JCYJ20150324140036853; the Science and Technology Program Fund of Shenzhen City of China, No. JCYJ20140418181958477.

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摘要：

脑电图是一种评价脑功能状况的敏感性指标，能在早期反映脑功能的变化及脑缺血严重程度，但其是否可以预测脑梗死后抑郁的病情发展，目前尚不可知。试验对321例中国广东的脑梗死患者进行Hamilton抑郁量表测评和脑电图检查，分析异常脑电图和脑梗死后抑郁的关系。结果显示，出现抑郁的缺血性脑卒中患者脑电图存在低振幅α波以及慢θ波，而出现与未出现抑郁的缺血性脑卒中患者脑电图均存在快β波和慢δ波。试验结果提示脑电图低振幅α波和慢θ波可能成为脑梗死后抑郁的独立预测因素。

orcid:0000-0001-8805-5476(Ping Luan)
         0000-0002-4078-7755(Jun Wang)

关键词: 神经再生, 脑血管病, 脑器质性精神障碍, 脑卒中, 缺血性脑卒中, 脑梗死后抑郁, 抑郁, 脑电图, Hamilton抑郁量表

Abstract:

Electroencephalography is a sensitive indicator for measuring brain condition, and can reflect early changes in brain function and severity of cerebral ischemia. However, it is not yet known whether electroencephalography can predict development of post-cerebral infarction depression. A total of 321 patients with ischemic stroke underwent electroencephalography and Hamilton Depression Rating Scale assessment to analyze the relationship between electroencephalography and post-cerebral infarction depression. Our results show that electroencephalograms of ischemic stroke patients with depression exhibit low-amplitude alpha activity and slow theta activity. In contrast,electroencephalograms of ischemic stroke patients without depression show fast beta activity and slow delta activity. These findings confirm that low-amplitude alpha activity and slow theta activity can be considered as independent predictors for post-cerebral infarction depression.

Key words: nerve regeneration, cerebrovascular disease, brain organic mental disorders, stroke, ischemic stroke, post-cerebral-infarction depression, depression, electroencephalography, Hamilton Depression Rating Scale, neural regeneration