中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (12): 1132-1138.doi: 10.3969/j.issn.1673-5374.2013.12.008

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

悬灸卒中大鼠尾温变化与灸效的相关性

  

  • 收稿日期:2012-06-28 修回日期:2013-01-24 出版日期:2013-04-25 发布日期:2013-04-25

Efficacy of suspended moxibustion in stroke rats is associated with a change in tail temperature

Rixin Chen1, Zhimai Lv2, Dangdang Huang3, Mingren Chen1, Fan Yi4   

  1. 1 Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China
    2 The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    3 Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
    4 Department of Health of Jiangxi Province, Nanchang 330006, Jiangxi Province, China
  • Received:2012-06-28 Revised:2013-01-24 Online:2013-04-25 Published:2013-04-25
  • Contact: Rixin Chen, Professor, Doctoral supervisor, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China, jxchenrixin@yahoo.com.cn.
  • About author:Rixin Chen and Zhimai Lv contributed equally to this work.
  • Supported by:

    国家重点基础研究发展计划（2009CB522902）；国家自然科学基金项目（81160453）；江西省卫生厅中医药科研基金（2011A008）

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摘要：

悬灸产生的热量可能从穴位传递到身体的其他部位，临床上感传现象消失则意味着灸量已足，可停止悬灸。在实验动物中是否也符合这一规律呢？实验建立了脑卒中模型大鼠，悬灸大椎治疗3d，结果显示卒中大鼠尾温在悬灸15min后开始升高，40min下降。悬灸卒中大鼠的大椎穴如伴随尾温升高，大鼠神经功能改善明显增强，且这一疗效与明显抑制肿瘤坏死因子α和白介素1β的mRNA有关，但悬灸40和60min的疗效无差异，提示悬灸40min时，升高的尾温开始下降，如若继续悬灸，对卒中大鼠的康复并无明显帮助。

关键词: 神经再生, 中医药, 针灸, 悬灸, 脑卒中, 尾温, 肿瘤坏死因子α, 白介素1β, 大椎, 基金资助文章

Abstract:

Suspended moxibustion-produced heat can transfer from the acupoint to other sites of the body. The suspended moxibustion should be terminated when clinical propagated sensation disappears, because this implies that the quantity of moxibustion is sufficient. We wanted to investigate if this phenomenon also occurs in experimental animals. In the present study, a rat model of stroke was established and treated with suspended moxibustion at Dazhui (DU14) for 60 minutes. Results showed that the increase in tail temperature began at 15 minutes after suspended moxibustion and decreased gradually at 40 minutes. In addition, neurological function was significantly improved in stroke rats with tail temperature increase following suspended moxibustion, and this effect was associated with significantly reduced tumor necrosis factor α and interleukin 1β mRNA. However, there was no significant difference between 40- and 60-minute suspended moxibustion. The findings indicate that elevated tail temperature began to decrease at 40 minutes after suspended moxibustion, and further suspended moxibustion was not useful in the recovery of stroke rats.

Key words: neural regeneration, traditional Chinese medicine, acupuncture and moxibustion, suspended moxibustion, stroke, tail temperature, tumor necrosis factor-alpha, interleukin-1 beta, grants-supported paper, neuroregeneration