中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (15): 1410-1417.doi: 10.3969/j.issn.1673-5374.2013.15.008

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

血管紧张素转换酶基因多态性与中国北方汉族大脑中动脉狭窄

  

  • 收稿日期:2012-06-21 修回日期:2012-12-04 出版日期:2013-05-25 发布日期:2013-05-25

Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population

Chunshu Rong1, 2, Yingqi Xing2, Xinmei Jiang2, Juan Wang2, Baoshan Gao3, Jianjun Zhao1, Kangding Liu2   

  1. 1 Department of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, Jilin Province, China
    2 Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
    3 Department of Urinary Surgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Received:2012-06-21 Revised:2012-12-04 Online:2013-05-25 Published:2013-05-25
  • Contact: Kangding Liu, M.D., Professor, Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China, kangdingliu@163.com.
  • About author:Chunshu Rong★, Master.

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摘要：

血管紧张素转换酶基因是脑卒中候选基因之一。实验选取148例经脑彩超检查证实为大脑中动脉狭窄的中国北方汉族患者和62例健康志愿者，采用聚合酶链式反应-限制性片段长度多态性测定外周血血管紧张素转换酶基因型。发现大脑中动脉狭窄患者中血管紧张素转换酶DD基因型和D等位基因频率有增高趋势，但增高的差异与健康自愿者比较并无显著性意义，说明中国北方汉族人群大脑中动脉狭窄的发生与血管紧张素转换酶基因的DD基因型及D等位基因频率无明显相关性。

关键词: 神经再生, 脑损伤, 脑卒中, 血管紧张素转换酶, 基因, 多态性, 大脑中动脉, 血管狭窄, 中国北方, 汉族

Abstract:

The angiotensin-converting enzyme gene is a candidate gene of stroke. The present study involved 62 healthy volunteers and 148 patients with middle cerebral artery stenosis as confirmed by brain color ultrasound from a Han population in North China, and determined the peripheral blood angiotensin-converting enzyme genotype using PCR-restriction fragment length polymorphism analysis. The results showed that the frequencies of the DD genotype and D allele were increased in patients with middle cerebral artery stenosis, but the difference was not statistically significant compared with healthy controls. The findings of this study on the relationship between stroke genes and middle cerebral artery stenosis indicate no significant correlation between the frequencies of the DD genotype and D allele of angiotensin-converting enzyme and middle cerebral artery stenosis in this Han population from North China. In the future, studies will be carried out to investigate correlations between multiple stroke candidate gene synergy and middle cerebral artery stenosis to provide a foundation for the development of gene therapy.