中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (17): 1615-1622.doi: 10.3969/j.issn.1673-5374.2013.17.010

• 原著:退行性病与再生 • 上一篇    下一篇

帕金森病患者生活质量的生态观：意大利东北西西里岛横断面调查

  

  • 收稿日期:2013-01-10 修回日期:2013-04-18 出版日期:2013-06-15 发布日期:2013-06-15

Health-related quality of life in Parkinson’s disease patients in northeastern Sicily, Italy
An ecological perspective

Letteria Spadaro, Lilla Bonanno, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino   

  1. Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi “Bonino Pulejo” Via Provinciale Palermo, C.da Casazza 98124 Messina, Italy
  • Received:2013-01-10 Revised:2013-04-18 Online:2013-06-15 Published:2013-06-15
  • Contact: Silvia Marino, M.D., Ph.D., IRCCS Centro Neurolesi “Bonino Pulejo” Via Provinciale Palermo, C.da Casazza 98124 Messina, Italy, silvimarino@gmail.com.
  • About author:Letteria Spadaro, Pys.

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摘要：

帕金森病导致的抑郁、认知缺损、运动障碍、步态异常和多巴胺能药物的使用严重影响患者的生活质量。我们对意大利东北西西里岛的帕金森病患者进行横断面调查，评估影响该地区帕金森病患者生活质量的因素。调查共纳入90例帕金森病患者，应用统一帕金森病评定量表运动分量表(UPDRS-III)、39项帕金森病调查表评估疾病相关的生活质量，以健康测量量表SF36评估患者总体生活质量。85例患者完成了量表评估。我们还以临床和社会变量作为生活质量的独立预测因素，进行多元回归分析。结果显示，生态个体和人际水平对帕金森病患者生活质量有潜在的复合影响。性别、自我评估和家庭人数明显影响患者生活质量。因此，如果以生活质量的改善为帕金森病治疗的目的，则应对其生态构架给予充分重视，加强个性化、有针对性的护理。

关键词: 神经再生, 临床实践, 神经退行性变, 健康相关生活质量, 生活质量, 帕金森病, 生态模式, 社会变量, 护理者, 量表, 基金资助文章

Abstract:

Parkinson’s disease has a negative impact on health-related quality of life in Parkinson’s disease patients. Depression, cognitive impairment, coping strategies, dyskinesia, gait disorders and complications of dopaminergic drugs are the variables that most affect health-related quality of life. The ecological model of human development focuses attention on both individual and social environmental factors as targets for health interventions. From this perspective, the aim of this cross-sectional survey was to evaluate the influence of gender, family size and perceived autonomy on health-related quality of life in Parkinson’s disease patients in northeastern Sicily, Italy. Ninety Parkinson’s disease patients, attending the Movement Disorders Clinic at IRCCS Centro Neurolesi “Bonino-Pulejo” (Messina), were consecutively enrolled. The Unified Parkinson Disease Rating Scale motor subscale (UPDRS-III) scores, the Parkinson Disease Questionnaire-39 Item scores (as a disease-specific measure of health-related quality of life), scores on the Short Form (36) Health Survey Questionnaire (as a generic measure), and answers to a brief checklist were recorded.
A total of 85 Parkinson’s disease patients (49% males and 51% females; mean age 70.8 ± 8.6 years; mean UPDRS-III 24.15 ± 6.55; mean disease duration 5.52 ± 4.65 years) completed the booklet of questionnaires. In the multivariate regression analysis, we included clinical and social variables as independent predictors of health-related quality of life. Our results suggest a potential compounding effect of ecological intrapersonal and interpersonal levels on health-related quality of life outcomes. Gender, self-evaluated autonomy and family size significantly impacted health-related quality of life. If quality of life is used as an indicator of treatment outcomes, an ecological perspective of the case history will be important to disclose relevant prognostic information and trigger personalized health care interventions.

Key words: neural regeneration, neurodegenerative disease, health-related quality of life, Parkinson’s disease, ecological model, Parkinson's Disease Questionnaire-39 Items, social variables, the Unified Parkinson Disease Rating Scale motor subscales, caregiver, grants-supported paper