中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (17): 1606-1614.doi: 10.3969/j.issn.1673-5374.2013.17.009

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

肿瘤化疗药物引起的神经退行性变及海马功能障碍

  

  • 收稿日期:2012-10-29 修回日期:2013-01-15 出版日期:2013-06-15 发布日期:2013-06-15

Neurotoxicity of cancer chemotherapy

Miyoung Yang1, 2, Changjong Moon1   

  1. 1 Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Republic of Korea
    2 Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
  • Received:2012-10-29 Revised:2013-01-15 Online:2013-06-15 Published:2013-06-15
  • Contact: Changjong Moon, D.V.M., M.S., Ph. D., Associate professor, Department of Veterinary Anatomy, College of Veterinary Medicine, Chonnam National University, 300 Yongbong-Dong, Buk-Gu, Gwangju 500-757, South Korea, moonc@chonnam.ac.kr.
  • About author:Miyoung Yang☆, D.V.M., M.S., Ph.D., Post-doctoral fellow, MSU, USA.

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摘要：

肿瘤化疗药物可引起包括记忆缺失和情绪障碍在内的神经系统副作用。文章聚集于化疗药物引发的神经退行性变和与记忆关系最为密切的海马功能障碍的体内和体外研究进展。这将为进一步研究化疗药物引发的神经系统副作用提供帮助，并为新型化疗药物的研发提供线索。

关键词: 神经再生, 神经退行性变, 神经发生, 综述, 行为障碍, 化疗, 海马功能障碍, 记忆缺失, 情绪障碍, 神经元, 神经可塑性, 神经毒性, 基金资助文章

Abstract:

There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.

Key words: neural regeneration, reviews, neurogenesis, behavioral dysfunction, chemotherapy, hippocampal dysfunction, memory deficit, mood disorder, neurodegeneration, neuron, neuroplasticity, neurotoxicity, grants-supported paper, neuroregeneration