中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (33): 3087-3094.doi: 10.3969/j.issn.1673-5374.2013.33.002

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓缺血再灌注损伤过程中体感诱发电位的监测

  

  • 收稿日期:2013-06-13 修回日期:2013-09-27 出版日期:2013-11-25 发布日期:2013-11-25
  • 基金资助:

    国家自然科学基金项目 (81101370, 811013998,1272018)；江苏省自然科学基金项目(BK2011303)；江苏省科技支撑计划(社会发展)(BE2011672)；江苏省高校自然科学研究项目 (12KJB320008)；江苏省普通高校研究生科研创新计(CXZZ11_0126)。

Monitoring somatosensory evoked potentials in spinal cord ischemia-reperfusion injury

Yiming Ji, Bin Meng, Chenxi Yuan, Huilin Yang, Jun Zou   

  1. Department of Orthopedic Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
  • Received:2013-06-13 Revised:2013-09-27 Online:2013-11-25 Published:2013-11-25
  • Contact: Jun Zou, Ph.D., Attending physician, Department of Orthopedic Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China, jzou@suda.edu.cn.
  • About author:Yiming Ji, Ph.D., Associate chief physician.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81101370, 81101399, 81272018; the Natural Science Foundation of Jiangsu Province in China, No. BK2011303; Jiangsu Province Science and Technology Support Program (Social Development) in China, No. BE2011672; University Natural Science Research Foundation of Jiangsu Province for Higher Education, No. 12KJB320008; College Graduate Research and Innovation Plan of Jiangsu Province in China, No. CXZZ11_0126

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摘要：

缺血等非机械性因素造成的脊髓缺血再灌注损伤是否也能用体感诱发电位进行监测呢？鉴于此，实验采用体感诱发电位检测技术监测兔脊髓缺血再灌注损伤过程。结果显示，在兔脊髓缺血期间，体感诱发电位的潜伏期明显延长，波幅明显降低，直至消失；再灌注后30-180 min，波幅和潜伏期又开始逐渐恢复；但在再灌注360 min，潜伏期与缺血前差异无显著性意义，体感诱发电位波幅又出现了降低，其下降幅度较大的兔后肢出现了严重的运动功能障碍。结果说明，体感诱发电位潜伏期的变化可反映脊髓缺血性损害程度；而波幅的变化可反映晚期的脊髓再灌注损伤程度，以此评估肢体的运动功能，最大限度避免医源性脊髓损伤。

关键词: 神经再生, 脊髓损伤, 体感诱发电位, 脊髓, 缺血, 再灌注损伤, 医源性脊髓损伤, 组织病理学, 腹主动脉阻断模型, 潜伏期, 再灌注期, 基金资助文章

Abstract:

It remains unclear whether spinal cord ischemia-reperfusion injury caused by ischemia and other non-mechanical factors can be monitored by somatosensory evoked potentials. Therefore, we monitored spinal cord ischemia-reperfusion injury in rabbits using somatosensory evoked potential detection technology. The results showed that the somatosensory evoked potential latency was significantly prolonged and the amplitude significantly reduced until it disappeared during the period of spinal cord ischemia. After reperfusion for 30–180 minutes, the amplitude and latency began to gradually recover; at 360 minutes of reperfusion, the latency showed no significant difference compared with the pre-ischemic value, while the somatosensory evoked potential amplitude in-creased, and severe hindlimb motor dysfunctions were detected. Experimental findings suggest that changes in somatosensory evoked potential latency can reflect the degree of spinal cord ischemic injury, while the amplitude variations are indicators of the late spinal cord reperfusion injury, which provide evidence for the assessment of limb motor function and avoid iatrogenic spinal cord injury.

Key words: neural regeneration, spinal cord injury, somatosensory evoked potentials, spinal cord, ischemia, reperfusion, iatrogenic spinal cord injury, histopathology, abdominal aorta occlusion model, latency, grants-supported paper, neuroregeneration