中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (36): 3410-3415.doi: 10.3969/j.issn.1673-5374.2013.36.006

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

即刻与延迟缝合修复坐骨神经的比较

  

  • 收稿日期:2013-10-18 修回日期:2013-11-23 出版日期:2013-12-25 发布日期:2013-12-25

Immediate versus delayed primary nerve repair in the rabbit sciatic nerve

Ahmet Piskin1, Berrin Zühal Altunkaynak2, Atilla Çıtlak3, Hicabi Sezgin1, Ozgür Yazıcı1, Süleyman Kaplan2   

  1. 1 Department of Orthopedics and Traumatology, School of Medicine, Ondokuz May?s University, Samsun, Turkey
    2 Department of Histology and Embryology, School of Medicine, Ondokuz May?s University, Samsun, Turkey
    3 Department of Orthopedics and Traumatology, School of Medicine, Giresun University, Giresun, Turkey
  • Received:2013-10-18 Revised:2013-11-23 Online:2013-12-25 Published:2013-12-25
  • Contact: Atilla ??tlak, M.D., Assistant professor, Department of Orthopedics and Traumatology, School of Medicine, Giresun University, Giresun, Turkey, atillacitlak@yahoo.com.
  • About author:Ahmet Piskin, Associate professor.

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摘要：

周围神经损伤后的缝合时间以即刻为宜，但有些情况下，该时间可能被推迟。为比较即刻与延迟神经缝合对损伤坐骨神经修复的效果。实验应用体视学、组织学和生物力学检测立即缝合与3d后缝合新西兰兔横断伤坐骨神经的修复情况。即刻与延迟神经缝合后8周，坐骨神经轴突数量和面积、髓鞘和神经外膜厚度、许旺细胞形态、神经纤维力学性能差异并不明显。说明延迟缝合对周围神经的修复无明显不利影响。

中国神经再生研究（英文版）杂志出版内容重点： 脑损伤；脊髓损伤；周围神经损伤；帕金森；神经影像；神经再生

关键词: 神经再生, 坐骨神经, 周围神经损伤, 周围神经再生, 延迟修复, 体视学, 显微镜, 生物力学

Abstract:

It is well known that peripheral nerve injury should be treated immediately in the clinic, but in some instances, repair can be delayed. This study investigated the effects of immediate versus delayed (3 days after injury) neurorrhaphy on repair of transected sciatic nerve in New Zealand rabbits using stereological, histomorphological and biomechanical methods. At 8 weeks after immediate and de-layed neurorrhaphy, axon number and area in the sciatic nerve, myelin sheath and epineurium thickness, Schwann cell morphology, and the mechanical property of nerve fibers did not differ ob-viously. These results indicate that delayed neurorrhaphy do not produce any deleterious effect on sciatic nerve repair.

Key words: neural regeneration, delayed peripheral nerve repair, sciatic nerve, peripheral nerve injury, stereology, microscopy, biomechanics, neuroregeneration