中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (36): 3434-3440.doi: 10.3969/j.issn.1673-5374.2013.36.009

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

血管生成素基因多态性是中国北方汉族人群糖尿病神经病的高危因素吗？

  

  • 收稿日期:2013-08-11 修回日期:2013-11-12 出版日期:2013-12-25 发布日期:2013-12-25
  • 基金资助:

    北京市自然科学基金项目, No. 7102161

Angiogenin gene polymorphism A risk factor for diabetic peripheral neuropathy in the northern Chinese Han population?

Hongli Wang, Dongsheng Fan, Yingshuang Zhang   

  1. Department of Neurology, Peking University Third Hospital, Beijing 100191, China
  • Received:2013-08-11 Revised:2013-11-12 Online:2013-12-25 Published:2013-12-25
  • Contact: Dongsheng Fan, Ph.D., Doctoral supervisor, Chief physician, Department of Neurology, Peking University Third Hospital, Beijing 100191, China, dsfan@sina.com.
  • About author:Hongli Wang, Ph.D., Attending physician.
  • Supported by:

    This study was financially sponsored by the Natural Science Foundation of Beijing, No. 7102161.

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摘要：

近期研究发现血管生长素与糖尿病神经病变相关。实验对207例中国北方汉族人群2型糖尿病患者（含129例糖尿病神经病变和78例无神经病变）和268例健康对照者进行外周血白细胞中血管生成素基因测序。结果发现糖尿病神经病变患者、无神经病变糖尿病患者与健康对照血管生成素基因外显子区单核苷酸多态性rs11701的基因型(T442T和T442G)和等位基因(442T和442G)分布频率接近。提示血管生成素基因可能与中国北方汉族人群糖尿病神经病变遗传易感性无关。

中国神经再生研究（英文版）杂志出版内容重点： 脑损伤；脊髓损伤；周围神经损伤；帕金森；神经影像；神经再生

关键词: 神经再生, 临床实践, 血管生成素, 单核苷酸多态性, 2型糖尿病, 糖尿病神经病变, 血管生成, 糖尿病微血管并发症, 遗传易感性, 高危因素, 周围神经损伤, 基金资助项目

Abstract:

Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se-quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus (129 diabetic peripheral neuropathy patients and 78 diabetic non-neuropathy pa-tients) and 268 healthy controls. All subjects were from the Han population of northern China. No mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.

Key words: neural regeneration, angiogenin, single nucleotide polymorphism, type 2 diabetes mellitus, diabetic peripheral neuropathy, angiogenesis, diabetic microvascular complications, genetic susceptibility, risk factor, peripheral nerve injury, grants-supported paper, neuroregeneration