中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (1): 51-60.doi: 10.4103/1673-5374.125330

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

脑卒中后大脑功能网络的改变

  

  • 收稿日期:2013-07-16 出版日期:2014-01-05 发布日期:2014-01-05
  • 基金资助:

    国家自然科学基金(60905024)

Changes in brain functional network connectivity after stroke

Wei Li1, 2, Yapeng Li1, 2, Wenzhen Zhu3, Xi Chen1, 2   

  1. 1 Key Laboratory of Image Processing and Intelligent Control, Ministry of Education, Wuhan, Hubei Province, China
    2 Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    3 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • Received:2013-07-16 Online:2014-01-05 Published:2014-01-05
  • Contact: Wei Li, Associate professor, Key Laboratory of Image Processing and Intelligent Control, Ministry of Education, Wuhan 430074, Hubei Province, China, Liwei 0828@mail.hust.edu.cn.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 60905024.

摘要:

有研究表明,功能网络连接模型可用来研究精神分裂症患者脑功能网络连接的改变,实验设想以此用于脑卒中患者脑功能网络连接变化的研究。实验采用独立成分分析法来确定脑卒中患者的运动区域,为确定运动区域的新方法。实验收集首次发病的右利手脑卒中患者和健康对照者的脑功能磁共振数据,利用独立成分分析方法进行数据分析,获得与实验范式相关性较高的6个成分,最后建立大脑功能网络连接模型观察两组大脑区域之间的连接变化。结果发现,健康对照组只存在4条连接,脑卒中患者存在11条连接。在脑卒中患者大脑主要运动区域中缺失的链接多为直接连接,通过间接连接或新环路的可建立新的关联,这些连接可能和脑卒中后康复程度存在直接的关联。结果提示,脑卒中患者大脑区域之间的功能连接更加复杂,在其大脑功能网络连接中存在补偿环路,这意味着功能补偿可能在脑卒中后的神经可塑性方面可发挥重要作用。

关键词: 神经再生用, 脑损伤用, 脑卒中用, 运动区域用, 功能磁共振用, 脑网络用, 功能网络连接用, 神经可塑

Abstract:

Studies have shown that functional network connection models can be used to study brain network changes in patients with schizophrenia. In this study, we inferred that these models could also be used to explore functional network connectivity changes in stroke patients. We used independent component analysis to find the motor areas of stroke patients, which is a novel way to determine these areas. In this study, we collected functional magnetic resonance imaging datasets from healthy controls and right-handed stroke patients following their first ever stroke. Using independent component analysis, six spatially independent components highly correlated to the experimental paradigm were extracted. Then, the functional network connectivity of both patients and controls was established to observe the differences between them. The results showed that there were 11 connections in the model in the stroke patients, while there were only four connections in the healthy controls. Further analysis found that some damaged connections may be compensated for by new indirect connections or circuits produced after stroke. These connections may have a direct correlation with the degree of stroke rehabilitation. Our findings suggest that functional network connectivity in stroke patients is more complex than that in hea-lthy controls, and that there is a compensation loop in the functional network following stroke. This implies that functional network reorganization plays a very important role in the process of rehabilitation after stroke.

Key words: nerve regeneration, brain injury, stroke, motor areas, functional magnetic resonance imaging, brain network, independent component analysis, functional network connectivity, neural plasticity, NSFC grant, neural regeneration