中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1457-1462.doi: 10.4103/1673-5374.165516

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

乳果糖干预早期肝性脑病机制:增强神经可塑性

  

  • 收稿日期:2015-07-02 出版日期:2015-09-28 发布日期:2015-09-28
  • 基金资助:

    国家自然科学基金(30873390)

Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy

Nan Yang, He Liu, Yao Jiang, Ji Zheng, Dong-mei Li, Chao Ji, Yan-yong Liu, Ping-ping Zuo   

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China
  • Received:2015-07-02 Online:2015-09-28 Published:2015-09-28
  • Contact: Yan-yong Liu, Ph.D. or Ping-ping Zuo, Ph.D., liuyanyong@126.com or Pingping_zuo@126.com.
  • Supported by:

    This study was supported by a grant from the National Natural Science Foundation of China, No. 30873390.

摘要:

乳果糖干预可改善早期肝性脑病的认知功能,但作用机制尚不清楚。我们通过Morris水迷宫试验评价乳果糖干预四氯化碳致早期肝性脑病大鼠的效果。免疫组织化学分析结果表明乳果糖可以显著促进模型大鼠海马区神经发生,增加神经元和星形胶质细胞的数量。Morris水迷宫结果表明,乳果糖有效缩短模型大鼠的寻台潜伏期。表明其能有效改善早期肝性脑病模型大鼠的认知障碍。作者认为,乳果糖能有效地提高早期肝性脑病大鼠认知功能的作用,是通过增强神经可塑性达到的。

关键词: 神经再生, 脑损伤, 肝性脑病, 早期肝性脑病, 乳果糖, 神经可塑性, 神经发生, Morris水迷宫, 认知, 大鼠, NeuN, GFAP, 国家自然科学基金

Abstract:

Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy.

Key words: nerve regeneration, brain injury, hepatic encephalopathy, lactulose, neuroplasticity, neurogenesis, Morris water maze, cognition, rats, neuronal nuclei, glial fibrillary acidic protein, NSFC grants, neural regeneration