中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (10): 1020-1024.doi: 10.4103/1673-5374.133163

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

左旋肉碱促进压榨伤坐骨神经结构恢复正常

  

  • 收稿日期:2014-03-20 出版日期:2014-05-26 发布日期:2014-05-26
  • 基金资助:

    土耳其Ataturk大学科学研究项目

L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments

Ümmü Zeynep Avsar 1, Umit Avsar 2, Ali Aydin 3, Muhammed Yayla 4, Berna Ozturkkaragoz 5, Harun Un 6, Murat Saritemur 7, Tolga Mercantepe 8   

  1. 1 Department of Medical Education, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
    2 Department of Family Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
    3 Department of Orthopedics and Traumatology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
    4 Department of Pharmacology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
    5 Department of Pharmacology, Faculty of Pharmacy, Agr? University, Agr?, Turkey
    6 Department of Biochemistry, Faculty of Pharmacy, Agr? University, Agr?, Turkey
    7 Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
    8 Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
  • Received:2014-03-20 Online:2014-05-26 Published:2014-05-26
  • Contact: ümmü Zeynep Avsar, Department of Medical Education, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey, zeynep.avsar@atauni.edu.tr.
  • Supported by:

    This study was supported by a grant from Ataturk University Scientific Experimental Project Office to Project Number 2012/07.

摘要:

已有研究显示,乙酰左旋肉碱对糖尿病大鼠损伤坐骨神经有保护作用。实验假设左旋肉碱对损伤坐骨神经有保护作用。实验结果显示,钳夹大鼠坐骨神经造成压榨伤的坐骨神经出现退行性变。给损伤坐骨神经大鼠左旋肉碱灌胃50 mg/kg和100 mg/kg 30d后,损伤的坐骨神经轴突和髓鞘面积、轴突直径和髓鞘直径、有髓鞘轴突密度接近正常;坐骨神经功能也明显改善,说明左旋肉碱对坐骨神经压榨伤有保护作用。

关键词: 神经再生, 周围神经损伤, 坐骨神经, 左旋肉碱, 神经保护, 压榨伤, 电镜, 轴突, 髓鞘

Abstract:

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.

Key words: nerve regeneration, peripheral nerve injury, sciatic nerve, L-carnitine, neuroprotection, crush injury, electron microscopy, axon, myelin sheath, neural regeneration 

中图分类号: