中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (6): 982-988.doi: 10.4103/1673-5374.158365

• 原著:视神经损伤修复保护与再生 • 上一篇    下一篇

视网膜与视神经疾病的干细胞眼科治疗研究:初步报告

  

  • 收稿日期:2015-03-20 出版日期:2015-06-18 发布日期:2015-06-18

Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

Jeffrey N. Weiss 1, Steven Levy 2, Alexis Malkin 3   

  1. 1 Retina Associates of South Florida, 5800 Colonial Drive, Suite 300, Margate, FL, USA
    2 MD Stem Cells, 412 Main Street, Suite I, Ridgefield, CT, USA
    3 Wilmer Eye Institute, The Johns Hopkins Hospital, 600 N. Wolfe Street, Wilmer 317, Baltimore, MD, USA
  • Received:2015-03-20 Online:2015-06-18 Published:2015-06-18
  • Contact: Steven Levy, M.D., stevenlevy@mdstemcells.com.

摘要:

干细胞眼科治疗研究(SCOTS)是一项经人体研究伦理委员会批准的临床试验,是目前为止,美国国立卫生研究院在临床试验注册数据库(www.clinicaltrials.gov Identifier NCT 01920867)注册的最大型眼科干细胞研究。SCOTS利用自体骨髓干细胞治疗视神经和视网膜疾病。治疗前后的眼科检测由美国约翰•霍普金斯医院Wilmer眼科研究所独立完成。纳入的1例27岁女性视神经病变患者,在纳入研究前已失明约5年。最佳矫正视力是右眼20/800,左眼20/4000。治疗后4个月,中心视力改善至右眼20/100,左眼20/40。

关键词: 干细胞, 视神经, 视神经病变, 眼科, 骨髓干细胞, 失明, 干细胞眼科治疗研究, SCOTS

Abstract:

In this report, we present the results of a single patient with optic neuropathy treated within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and is the largest ophthalmology stem cell study registered at the National Institutes of Health to date- www.clinicaltrials.gov Identifier NCT 01920867. SCOTS utilizes autologous bone marrow-derived stem cells in the treatment of optic nerve and retinal diseases. Pre- and post-treatment comprehensive eye exams were independently performed at the Wilmer Eye Institute at the Johns Hopkins Hospital, USA. A 27 year old female patient had lost vision approximately 5 years prior to enrollment in SCOTS. Pre-treatment best-corrected visual acuity at the Wilmer Eye Institute was 20/800 Right Eye (OD) and 20/4,000 Left Eye (OS). Four months following treatment in SCOTS, the central visual acuity had improved to 20/100 OD and 20/40 OS.

Key words: stem cells, optic nerve, optic neuropathy, ophthalmology, bone marrow-derived stem cells, blindness, visual loss