中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (1): 119-125.doi: 10.4103/1673-5374.175056

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

注意力缺陷多动障碍患者脑连接存在性别差异?

  

  • 收稿日期:2015-12-20 出版日期:2016-01-15 发布日期:2016-01-15
  • 基金资助:

    韩国基础科学研究所资助(IBS-R015-D1)

Connectivity differences between adult male and female patients with attention deficit hyperactivity disorder according to resting-state functional MRI

Bo-yong Park 1, Hyunjin Park 2, 3   

  1. 1 Department of Electronic, Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Korea
    2 School of Electronic Electrical Engineering, Sungkyunkwan University, Suwon, Korea
    3 Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science, Suwon, Korea
  • Received:2015-12-20 Online:2016-01-15 Published:2016-01-15
  • Contact: Hyunjin Park, Ph.D.,hyunjinp@skku.edu.
  • Supported by:

    This study was supported in part by the Institute for Basic Science (to HP), No. IBS-R015-D1.

摘要:

注意力缺陷多动障碍作为一种常见的心理障碍疾病,不仅可在儿童期发病,在成人期的发病也不少见。成年男性和女性患者注意力缺陷多动障碍的表现存在差异,但几乎未见性别差异的量化研究。此次研究基于静息态功能MRI和脑连接分析量化成年女性和男性注意力缺陷多动障碍患者差异。男女脑连接差异以度中心度表示。发现额下回、额中回、额内侧回、顶上小叶, 楔前叶,缘上回,颞上回,颞中回,枕中回和楔叶为存在性别差异的脑区,且这些脑区与精神疾病诊断与统计手册DSM抑郁和焦虑评分呈正相关。研究从脑连接层面,为理解成年注意力缺陷多动障碍患者焦虑和抑郁表现存在性别差异的原因提供了新视角。

关键词: 神经再生, 脑连接, 注意力缺陷多动障碍, 性别差异, 功能MRI, 抑郁, 焦虑, 网络分析, 中心度, DSM评分

Abstract:

Attention deficit hyperactivity disorder (ADHD) is a pervasive psychiatric disorder that affects both children and adults. Adult male and female patients with ADHD are differentially affected, but few studies have explored the differences. The purpose of this study was to quantify differences between adult male and female patients with ADHD based on neuroimaging and connectivity analysis. Resting-state functional magnetic resonance imaging scans were obtained and preprocessed in 82 patients. Group-wise differences between male and female patients were quantified using degree centrality for different brain regions. The medial-, middle-, and inferior-frontal gyrus, superior parietal lobule, precuneus, supramarginal gyrus, superior- and middle-temporal gyrus, middle occipital gyrus, and cuneus were identified as regions with significant group-wise differences. The identified regions were correlated with clinical scores reflecting depression
and anxiety and significant correlations were found. Adult ADHD patients exhibit different levels of depression and anxiety depending on sex, and our study provides insight into how changes in brain circuitry might differentially impact male and female ADHD patients.

Key words: neural regeneration, connectivity, attention deficit hyperactivity disorder, sex difference, functional magnetic resonance imaging, depression, anxiety, network analysis, degree centrality, diagnostic and statistical manual score