中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (8): 1327-1332.doi: 10.4103/1673-5374.189199

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

基于功能电刺激的脊髓运动功能重建

  

  • 出版日期:2016-08-31 发布日期:2016-08-31
  • 基金资助:
    国家自然科学基金(81371663, 61534003)

Rebuilding motor function of the spinal cord based on functional electrical stimulation

Xiao-yan Shen1, 2, *, Wei Du1, Wei Huang1, Yi Chen3   

  1. 1 Electronic Information School, Nantong University, Nantong, Jiangsu Province, China 2 Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China 3 Medical School, Nantong University, Nantong, Jiangsu Province, China
  • Online:2016-08-31 Published:2016-08-31
  • Contact: Xiao-yan Shen, Ph.D., xiaoyansho@ntu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81371663, 61534003; and the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions of China, No. PPZY2015B135.

摘要:

重建由于脊髓损伤引起的运动功能是临床神经科学面临的最严峻挑战之一,通过功能电刺激可使损伤处以下的神经通路恢复功能。实验利用功能电刺激方法对大鼠腰骶段脊髓进行运动功能定位,绘制出腰骶段脊髓运动功能电刺激位点与肌肉的拓扑映射关系的三维图谱,根据实验个体参数及归一化处理后的运动功能位点坐标,确认控制相关肌肉的脊髓功能位点,以一定时相的脉冲序列对脊髓相关功能位点进行交叉控制,成功诱发大鼠后肢髋关节及踝关节的伸屈运动。实验成功建立了可描述脊髓运动功能位点的三维立体图谱,可为脊髓损伤后肢体运动功能恢复过程中电刺激治疗位点的选择提供指导。 

orcid: 0000-0003-4551-186X (Xiao-yan Shen)

关键词: 神经再生, 脊髓损伤, 功能电刺激, 运动功能重建, 运动控制, 脊髓, 脊髓腰骶段 运动功能位点, 伸髋运动, 屈髋运动, 跖屈, 背屈

Abstract: Rebuilding the damaged motor function caused by spinal cord injury is one of the most serious challenges in clinical neuroscience. The function of the neural pathway under the damaged sites can be rebuilt using functional electrical stimulation technology. In this study, the locations of motor function sites in the lumbosacral spinal cord were determined with functional electrical stimulation technology. A three-dimensional map of the lumbosacral spinal cord comprising the relationship between the motor function sites and the corresponding muscle was drawn. Based on the individual experimental parameters and normalized coordinates of the motor function sites, the motor function sites that control a certain muscle were calculated. Phasing pulse sequences were delivered to the determined motor function sites in the spinal cord and hip extension, hip ?exion, ankle plantar?exion, and ankle dorsi?exion movements were successfully achieved. The results show that the map of the spinal cord motor function sites was valid. This map can provide guidance for the selection of electrical stimulation sites during the rebuilding of motor function after spinal cord injury.

Key words: nerve regeneration, spinal cord injury, functional electrical stimulation, rebuilding motor function, movement control, spinal cord, lumbosacral spinal cord, motor function sites, hip extension movement, hip flexion movement, ankle plantarflexion, ankle dorsiflexion, neural regeneration