中国神经再生研究(英文版) ›› 2020, Vol. 15 ›› Issue (11): 2067-2072.doi: 10.4103/1673-5374.276337

• 原著:退行性病与再生 • 上一篇    下一篇

水上运动调节帕金森病患者的氧化应激状态

  

  • 出版日期:2020-11-15 发布日期:2020-08-21
  • 基金资助:

    这项研究得到了尼古拉·佩索尔·德尼索维尔高级合作社(CAPES),中央科学技术委员会(CNPq),南安帕罗·佩斯基萨·埃斯多多·南里奥格兰德州(FAPERGS)支持的财政支持

Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson’s disease

Caroline Dani 1, 4 , Isabel Teixeira Proença 1 , Jessica Marinho 1 , Pâmela Peccin 2 , Ivy Reichert Vital da Silva 1 , Simone Nique 2 , Vera Striebel 2 , Daniela Pochmann 1 , Viviane Rostirola Elsner 1, 2, 3#br#   

  1. 1 Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil
    2 Curso de Fisioterapia do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil
    3 Programa de Pós Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    4 Programa de Pós Graduação em Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
  • Online:2020-11-15 Published:2020-08-21
  • Contact: Caroline Dani, PhD,carolinedani@yahoo.com.br.
  • Supported by:
    This study was financially supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) for financial support.

摘要:

氧化应激是帕金森病重要的发病机制之一。为分析水上运动对帕金森病氧化应激水平的影响,对帕金森病患者进行水上运动干预1个月,每周2次(1h/次)。结果发现水上运动可增加帕金森病患者血浆超氧化物歧化酶活性,降低过氧化氢酶活性,且以干预后立即和干预后30d作用更为明显。结果表明,水上运动可调节帕金森病患者氧化应激状态。

orcid: 0000-0003-0046-7148 (Caroline Dani)

关键词:

运动疗法, 水上运动, 氧化应激, 帕金森病, 抗氧化剂, 抗氧化酶, 神经退行性疾病

Abstract: Parkinson’s disease is a neurodegenerative disease. Oxidative stress, i.e., the imbalance between the gen- eration of reactive oxygen species and the antioxidant defense capacity of the body, plays an important role in the pathogenesis of this disease. Physical exercise can regulate oxidative stress. The purpose of this study was to analyze the short- and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson’s disease. The aquatic exercise program was carried out during 1 month with two sessions per week (1 hour/session). Blood samples were collected at four different time points: pre-intervention, immediately, 48 hours, and 30 days after the first session of aquatic exercise program. Our results revealed that water-based programs modulated antioxidant enzyme activity, increased superoxide dismutase activity, reduced catalase activity, and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson’s disease. Compared with pre-intervention and 48 hours after the first session of aquatic exercise program, superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session. Our results demonstrated that aquatic exercise program could modulate oxidative stress, mainly by the effect of antioxidant enzyme activity. These results could better help understand the target of oxidative stress in Parkinson’s disease. This study was approved by the Ethics Committee of Centro Universitário Metodista IPA (approval No. 1.373.911) on August 9, 2019 and registered with REBEC (registration number: RBR-6NJ4MK).

Key words: antioxidant enzyme, antioxidants, aquatic exercise, exercise therapies, neurodegenerative disease, oxidative stress, Parkinson’s disease