中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2638-2644.doi: 10.4103/1673-5374.373678

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

脑卒中诱导免疫抑制中的分子伴侣

  

  • 出版日期:2023-12-15 发布日期:2023-06-14
  • 基金资助:
    国家自然科学基金项目(82172147,81571880,81373147,30901555,30972870);湖南省自然科学基金项目(2021JJ30900,2016JJ2157)

Molecular chaperones in stroke-induced immunosuppression

Haoduo Qiao1, 2, 3, 4, Qing Xu1, 2, 3, 4, Yunfei Xu1, 2, 3, 4, Yao Zhao1, 2, 3, 4, Nina He1, 2, 3, 4, Jie Tang5, Jie Zhao1, 2, 3, 4, *, Ying Liu1, 2, 3, 4, *   

  1. 1Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 2Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China; 3Sepsis Translational Medicine Key Laboratory of Hunan Province, Changsha, Hunan Province, China; 4National Medicine Functional Experimental Teaching Center, Changsha, Hunan Province, China; 5Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Ying Liu, PhD, liu1977ying@csu.edu.cn; Jie Zhao, PhD, steelzj@csu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82172147 (to YL), 81571880 (to YL), 81373147 (to YL), 30901555 (to JZ), 30972870 (to YL) and the Natural Science Foundation of Hunan Province, Nos. 2021JJ30900, 2016JJ2157 (both to YL). 

摘要:

脑卒中诱导的免疫抑制是导致脑卒中后免疫系统外周抑制的过程,也是一种中枢神经系统损伤诱导的免疫抑制综合征。脑卒中诱导的免疫抑制会增加脑卒中后尿路感染和脑卒中相关肺炎等感染的风险,恶化患者预后。分子伴侣是一类能够协助靶蛋白折叠、移位、复性及降解以维持蛋白稳态的蛋白。有证据表明,多种分子伴侣可通过调节分子伴侣、共孔蛋白及其相关通路的活性,可在脑卒中诱导的免疫抑制中发挥多种作用。此次综述总结了热休克蛋白等分子伴侣在脑卒中诱导的免疫抑制中的作用,并讨论了脑卒中后恢复免疫防御的新方法。

https://orcid.org/0000-0001-7922-600X (Haoduo Qiao); https://orcid.org/0000-0003-3392-5977 (Ying Liu); https://orcid.org/0000-0003-3760-4038 (Jie Zhao); https://orcid.org/0000-0002-4642-1850 (Qing Xu);

https://orcid.org/0000-0001-8017-9263 (Yunfei Xu); https://orcid.org/0000-0001-9233-0805 (Yao Zhao); 

https://orcid.org/0009-0003-9164-4687 (Nina He); https://orcid.org/0000-0002-3538-4433 (Jie Tang)

关键词: 脑卒中, 脑卒中诱导免疫抑制, 分子伴侣, 下丘脑-垂体-肾上腺轴, 交感神经系统, 神经保护, 热休克蛋白70, 热休克蛋白90, 热休克蛋白B5, 热休克蛋白72

Abstract: Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome. Stroke-induced immunosuppression leads to increased susceptibility to post-stroke infections, such as urinary tract infections and stroke-associated pneumonia, worsening prognosis. Molecular chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains, refolding misfolded proteins, and targeting misfolded proteins for degradation. Various molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones, cochaperones, and their associated pathways. This review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.

Key words: Hsp70, Hsp72, Hsp90, HspB5, hypothalamic-pituitary-adrenal axis, molecular chaperones, neuroprotection, stroke, stroke-induced immunosuppression, sympathetic nervous system