中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (12): 2054-2059.doi: 10.4103/1673-5374.172326

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受损较轻皮质脊髓束激活后的偏瘫患儿运动功能差:弥散张量纤维束成像验证

  

  • 收稿日期:2015-08-06 出版日期:2015-12-30 发布日期:2015-12-30

Activation of less affected corticospinal tract and poor motor outcome in hemiplegic pediatric patients: a diffusion tensor tractography imaging study

Jin Hyun Kim, Su Min Son*   

  1. Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Daegu, Republic of Korea
  • Received:2015-08-06 Online:2015-12-30 Published:2015-12-30
  • Contact: Su Min Son, M.D., Ph.D.,sumin430@hanmail.net.
  • Supported by:

    This study was supported by 2013 Yeungnam University Research Grant.

摘要:

受影响较小的大脑半球在成年大脑损害后运动功能恢复中有重要作用,但尚未见儿科患者受损较轻皮质脊髓束与运动功能结局相关性的研究。研究纳入40例由于围产期损伤致偏瘫的13.7 ± 3.0月龄患儿和40例年龄匹配的正常对照。患儿还被分为运动功能好和差2组。弥散张量纤维束成像检查显示,与对照组比较,40例患儿受损较轻的皮质脊髓束表现出更多的神经纤维数量和更低的各向异性值。与运动功能好组比较,功能差组神经纤维数量更多,而各向异性值更低。结果证明,表现为高神经纤维数量值和低各向异性值的受损较轻大脑激活的偏瘫患儿运动功能较差。

关键词: 神经再生, 脑区激活, 偏瘫, 皮质脊髓束, 弥散张量成像, 运动功能

Abstract:

The less affected hemisphere is important in motor recovery in mature brains. However, in terms of motor outcome in immature brains, no study has been reported on the less affected corticospinal tract in hemiplegic pediatric patients. Therefore, we examined the relationship between the condition of the less affected corticospinal tract and motor function in hemiplegic pediatric patients. Forty patients with hemiplegia due to perinatal or prenatal injury (13.7 ± 3.0 months) and 40 age-matched typically developing controls were recruited. These patients were divided into two age-matched groups, the high functioning group (20 patients) and the low functioning group (20 patients) using functional level of hemiplegia scale. Diffusion tensor tractography images showed that compared with the control group, the patient group of the less affected corticospinal tract showed significantly increased fiber number and significantly decreased fractional anisotropy value. Significantly increased fiber number and significantly decreased fractional anisotropy value in the low functioning group were observed than in the high functioning group. These findings suggest that activation of the less affected hemisphere presenting as increased fiber number and decreased fractional anisotropy value is related to poor motor function in pediatric hemiplegic patients.

Key words: nerve regeneration, unaffected hemisphere, hemiplegia, corticospinal tract, diffusion tensor imaging, motor function, neural regeneration