中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (6): 1015-1024.doi: 10.4103/1673-5374.184506

• 影像图片 • 上一篇    

骨髓间充质干细胞治疗缺血性脑卒中的多重作用机制及优化策略

  

  • 收稿日期:2016-03-18 出版日期:2016-06-30 发布日期:2016-06-30
  • 基金资助:

    黑龙江省自然科学基金项目(H2015083),牡丹江医学院项目(2013016)

Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies

Guihong Li1, 2, Fengbo Yu3, Ting Lei1, Haijun Gao1, Peiwen Li1, Yuxue Sun1, Haiyan Huang1, *, Qingchun Mu2, *   

  1. 1 Department of Neurosurgery, the First Hospital of Jilin University, Changchun, Jilin Province, China 2 Department of Neurosurgery, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China 3 School of Pharmacy, Mudanjiang Medical University, Mudanjiang, Heilongjiang Province, China
  • Received:2016-03-18 Online:2016-06-30 Published:2016-06-30
  • Contact: Qingchun Mu, M.D., Ph.D. or Haiyan Huang, M.D., Ph.D., muqc@qq.com or huanghy@jlu.edu.cn.
  • Supported by:

    This work was supported by the Natural Science Foundation of Heilongjiang Province of China, No. H2015083; and a grant from Higher Education Reform Project of Mudanjaing Medical University of China, No. 2013016.

摘要:

骨髓间充质干细胞对脑缺血的治疗作用已得到动物和临床研究的证实,但其复杂的作用机制尚待进一步研究。我们就应用于脑缺血治疗的骨髓间充质干细胞的来源、移植途径、定向迁移效果、分化替代及重建神经环路、血管发生、神经营养因子的分泌、细胞凋亡、免疫调制,以及骨髓间充质干细胞治疗缺血性脑卒中的作用机制的多重性、提高骨髓间充质干细胞治疗缺血性脑卒中效能的优化策略进行了概述。另外,我们还对临床研究中骨髓间充质干细胞移植的安全性问题进行了探讨,认为骨髓间充质干细胞移植是未来治疗脑缺血的一个重要方向,同时认为移植的最佳时间窗、最优注射剂量仍是今后研究中的重要的方向。 

orcid: 0000-0003-1082-2692 (Qingchun Mu)

关键词: 神经再生, 缺血性脑卒中, 缺血再灌注损伤, 骨髓间充质干细胞, 动物模型, 作用机制, 优化措施, 临床应用, 研究进展

Abstract:

Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction, angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action, and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke. We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.

Key words: nerve regeneration, ischemia/reperfusion injury, animal model, mechanisms of action, clinical application, research progress, genetic modification, angiogenesis, replacement therapy, neural regeneration