关键词: 阿尔茨海默病,  多巴胺能系统,  多巴胺,  多巴胺受体,  信号通路,  治疗,  中医药,  药物不良反应,  神经退行性疾病,  儿茶酚胺,  神经递质

Abstract: Alzheimer’s disease is a common neurodegenerative disorder in older adults. Despite its prevalence, its pathogenesis remains unclear. In addition to the most widely accepted causes, which include excessive amyloid-beta aggregation, tau hyperphosphorylation, and deficiency of the neurotransmitter acetylcholine, numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this condition. Dopamine is a crucial catecholaminergic neurotransmitter in the human body. Dopamine-associated treatments, such as drugs that target dopamine receptor D and dopamine analogs, can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical manifestations. However, therapeutics targeting the dopaminergic system are associated with various adverse reactions, such as addiction and exacerbation of cognitive impairment. This review summarizes the role of the dopaminergic system in the pathology of Alzheimer’s disease, focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related drugs. The aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer’s disease, thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

Key words: adverse drug reaction,  Alzheimer’s disease,  catecholamine,  dopamine receptor,  dopamine receptor heterodimers,  dopaminergic system,   neurodegenerative disease,  neurotransmitter,  signaling pathways,  traditional Chinese medicine,  treatment