中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (12): 2141-2146.doi: 10.4103/1673-5374.262594

• 原著:退行性病与再生 • 上一篇    下一篇

扩散峰度成像参数可用于鉴别阿尔茨海默病、遗忘型轻度认知障碍与正常衰老者

  

  • 出版日期:2019-12-15 发布日期:2019-12-15
  • 基金资助:

    上海市教委高峰临床医学项目(2016427)号，上海申康医院发展中心临床科技创新项目（SHDC22015038），上海市科委医疗指南项目（16411968900）

Differentiating between Alzheimer’s disease, amnestic mild cognitive impairment, and normal aging via diffusion kurtosis imaging

Guo-Ping Song , Ting-Ting Yao , Dan Wang, Yue-Hua Li   

  1. Institute of Diagnostic and Interventional Radiology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai, China
  • Online:2019-12-15 Published:2019-12-15
  • Contact: Yue-Hua Li, PhD, MD, liyuehua312@163.com.
  • Supported by:

    This study was supported by the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine in China, No. 2016427 (to YHL); the Clinical Science and Technology Innovation Project of Shanghai Shen Kang Hospital Development Center in China, No. SHDC22015038 (to YHL); the Shanghai Municipal Science and Technology Commission Medical Guide Project in China, No. 16411968900 (to YHL).

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摘要：

扩散峰度成像可以用于评估组织结构病理生理学变化，可用于中枢神经系统疾病的诊断，但其在评估阿尔茨海默病和遗忘型轻度认知障碍患者海马差异方面的敏感性还有待研究。因此，试验于上海交通大学附属上海市第六人民医院招募了阿尔茨海默病患者(男11例，女9例，年龄73.2±4.49岁)、遗忘型轻度认知障碍患者(男10例，女10例，年龄71.55±4.77岁)和正常衰老者(男11人，女9人，年龄70.45±5.04岁)，以3.0T MR扫描仪行扩散峰度成像分析3组海马的差异。结果显示：（1）阿尔茨海默病患者右侧海马容积、两侧海马平均峰度明显小于遗忘型轻度认知障碍和正常衰老者；（2）遗忘型轻度认知障碍患者海马平均峰度低于正常衰老者；（3）阿尔茨海默病患者左侧海马平均扩散系数低于遗忘型轻度认知障碍和正常衰老者，右侧海马平均扩散系数仅低于正常衰老者；（4）3组海马分数各向异性接近；（5）提示诊断阿尔茨海默病和遗忘型轻度认知障碍时，双侧海马平均峰度和平均扩散系数更为敏感。试验已于2010-05-01经上海交通大学附属上海市第六人民医院伦理委员会批准，批准号2010(C)-6，并获得所有参与者或其法定监护人的知情同意。

orcid: 0000-0001-8028-248X(Yue-Hua Li)

关键词: 磁共振成像, 扩散峰度成像, 海马, 遗忘性轻度认知功能障碍, 阿尔茨海默病, 平均峰度, 平均扩散系数, 分数各向异性, 神经再生

Abstract:

Diffusion kurtosis imaging can be used to assess pathophysiological changes in tissue structure and to diagnose central nervous system diseases. However, its sensitivity in assessing hippocampal differences between patients with Alzheimer’s disease and those with amnestic mild cognitive impairment has not been characterized. Here, we examined 20 individuals with Alzheimer’s disease (11 men and 9 women, mean 73.2 ± 4.49 years), 20 with amnestic mild cognitive impairment (10 men and 10 women, mean 71.55 ± 4.77 years), and 20 normal controls (11 men and 9 women, mean 70.45 ± 5.04 years). We conducted diffusion kurtosis imaging, using a 3.0 T magnetic resonance scanner, to compare hippocampal differences among the three groups. The results demonstrated that the right hippocampal volume and bilateral mean kurtosis were remarkably smaller in individuals with Alzheimer’s disease compared with those with amnestic mild cognitive impairment and normal controls. Further, the mean kurtosis was lower in the amnestic mild cognitive impairment group compared with the normal control group. The mean diffusion in the left hippocampus was lower in the Alzheimer’s disease group than in the amnestic mild cognitive impairment and normal control groups, while the mean diffusion in the right hippocampus was lower in the Alzheimer’s disease group than in the normal control group. Fractional anisotropy was similar among the three groups. These results verify that bilateral mean kurtosis and mean diffusion are sensitive to the diagnosis of Alzheimer’s disease and amnestic mild cognitive impairment. This study was approved by the Ethics Review Board of Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, China on May 4, 2010 (approval No. 2010(C)-6).

Key words: nerve regeneration, magnetic resonance imaging, diffusion kurtosis imaging, hippocampus, amnestic mild cognitive impairment, Alzheimer’s disease, mean kurtosis, mean diffusion, fractional anisotropy, neural regeneration