中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (10): 922-929.doi: 10.3969/j.issn.1673-5374.2013.10.007

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

低强度训练复合光照促进成年大鼠大脑神经发生

  

  • 收稿日期:2012-11-09 修回日期:2013-02-16 出版日期:2013-04-05 发布日期:2013-04-05

Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain

Sung Jin Kwon1, Jeongsook Park2, So Yun Park2, Kwang Seop Song1, Sun Tae Jung1, So Bong Jung1, Ik Ryeul Park3, Wan Sung Choi2, Sun Ok Kwon1   

  1. 1 Department of Physical Education, Gyeongsang National University, Jinju 660-701, Republic of Korea
    2 Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, School of Medicine, Gyeongsang National University, Jinju 660-751, Republic of Korea
    3 Department of Liberal Arts, Gyeongnam National University of Science and Technology, Jinju 660-758, Republic of Korea
  • Received:2012-11-09 Revised:2013-02-16 Online:2013-04-05 Published:2013-04-05
  • Contact: Wan Sung Choi, Ph.D., Professor, Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, School of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju, Gyeongnam 660-751, Republic of Korea, choiws@gnu.ac.kr. Sun Ok Kwon, Ph.D., Professor, Department of Physical Education, Gyeongsang National University, 900 Gajwa-Dong Jinju Gyeongnam 660-701, Republic of Korea, kwon502@gnu.ac.kr.
  • About author:Sung Jin Kwon☆, Ph.D., Researcher.

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摘要：

海马是参与学习和记忆功能的主要大脑部位。实验给予雄性成年SD大鼠运动训练和/或光照干预，以证实运动和光照这两个因素可促进非发育期海马神经可能发生的假设。运动训练为低强度平板运动训练，包括以2m/min 速度跑步5min；以5m/min速度跑步5min；以8m/min速度跑步20min。光照干预为10 000 lx，每周5天，30 min/d，共4周。结果显示，运动训练或光照均促进大鼠海马齿状回神经发生，提高海马脑源性神经营养因子的表达。运动训练复合光照对成年大鼠海马齿状回神经发生有明显促进作用，但对海马脑源性神经营养因子的表达则无明显影响。说明低强度运动训练和/或光照干预对大鼠大脑神经发生有促进作用。提示较低强度的户外锻炼活动对儿童的神经系统发育及防止老年人认知功能的减退都大有裨益。

关键词: 神经再生, 神经发生, 神经康复, 运动, 训练, 光照, 神经发生, 神经营养因子, 海马, 儿童, 基金资助文章

Abstract:

The hippocampus is a brain region responsible for learning and memory functions. The purpose of this study was to investigate the effects of low-intensity exercise and bright light exposure on neurogenesis and brain-derived neurotrophic factor expression in adult rat hippocampus. Male Sprague-Dawley rats were randomly assigned to control, exercise, light, or exercise + light groups (n = 9 per group). The rats in the exercise group were subjected to treadmill exercise (5 days per week, 30 minutes per day, over a 4-week period), the light group rats were irradiated (5 days per week, 30 minutes per day, 10 000 lx, over a 4-week period), the exercise + light group rats were subjected to treadmill exercise in combination with bright light exposure, and the control group rats remained sedentary over a 4-week period. Compared with the control group, there was a significant increase in neurogenesis in the hippocampal dentate gyrus of rats in the exercise, light, and exercise + light groups. Moreover, the expression level of brain-derived neurotrophic factor in the rat hippocampal dentate gyrus was significantly higher in the exercise group and light group than that in the control group. Interestingly, there was no significant difference in brain-derived neurotrophic factor expression between the control group and exercise + light group. These results indicate that low-intensity treadmill exercise (first 5 minutes at a speed of 2 m/min, second 5 minutes at a speed of 5 m/min, and the last 20 minutes at a speed of 8 m/min) or bright-light exposure therapy induces positive biochemical changes in the brain. In view of these findings, we propose that moderate exercise or exposure to sunlight during childhood can be beneficial for neural development.

Key words: neural regeneration, neurogenesis, neurorehabilitation, exercise, bright light, brain-derived neurotrophic factor, hippocampus, childhood, grants-supported paper, neuroregeneration