中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (14): 1276-1285.doi: 10.3969/j.issn.1673-5374.2013.14.004

• 原著:退行性病与再生 • 上一篇    下一篇

帕金森病伴痴呆患者脑灰质结构的改变

  

  • 收稿日期:2013-02-11 修回日期:2013-04-20 出版日期:2013-05-15 发布日期:2013-05-15

Changes of brain gray matter structure in Parkinson’s disease patients with dementia

Jianguo Xia1, Jinlin Miu2, Hongbin Ding1, Xiuping Wang1, Hua Chen1, Juan Wang3, Juan Wu4, Jingli Zhao4, Huanxin Huang5, Weizhong Tian1   

  1. 1 Department of Radiology, Taizhou People’s Hospital, Taizhou 225300, Jiangsu Province, China
    2 Department of Radiology, the Fourth People’s Hospital of Taizhou, Taizhou 225300, Jiangsu Province, China
    3 Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
    4 Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
    5 Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
  • Received:2013-02-11 Revised:2013-04-20 Online:2013-05-15 Published:2013-05-15
  • Contact: Weizhong Tian, Master, Chief physician, Department of Radiology, Taizhou People’s Hospital, Taizhou 225300, Jiangsu Province, China, tz_twz@163.com.
  • About author:Jianguo Xia★, Master, Associate chief physician.

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摘要：

帕金森病伴痴呆的基于体素的形态学测量方法是目前国际研究的热点。文章采用三维快速扰相位梯度回波序列对12例帕金森病伴痴呆和12例无痴呆的帕金森病患者进行扫描，应用体素的形态学分析方法，通过统计参数图软件5对患者的灰质数据进行计算，数据的灰质体积差异采用国际通用的统计参数图表示。结果发现，与无痴呆的帕金森病患者相比，帕金森病伴痴呆患者脑灰质体积异常减少的脑区包括：右颞上回、左颞上回、左侧额下回、两侧后扣带回、左侧扣带回、右侧海马旁回、海马、右侧楔前叶、楔叶及左侧岛叶。未见灰质体积明显增加的脑区。作者认为，边缘系统及大脑新皮质的体积缺失与帕金森病患者的痴呆关系密切。

关键词: 神经再生, 神经退行性疾病, 神经影像学, 体素的形态学测量, 帕金森病, 痴呆, 灰质异常, 边缘系统, 基金资助文章

Abstract:

Voxel-based morphometry is gaining considerable interest for studies examining Parkinson’s disease dementia patients. In this study, 12 patients with clinically defined Parkinson’s disease and dementia and 12 non-demented patients with Parkinson’s disease were examined using a T1WI three-dimensional fast spoiled gradient echo sequence. Gray matter data were analyzed using a voxel-based morphometry method and independent sample t-test based on Statistical Parametric Mapping 5 software. Differences in gray matter volume were represented with statistical parametric mapping. Compared with Parkinson’s disease patients without dementia, decreased gray matter volume in Parkinson’s disease dementia patients was observed in the bilateral superior temporal gyrus, bilateral posterior cingulate and left cingulate gyrus, right parahippocampal gyrus and hippocampus, right precuneus and right cuneus, left inferior frontal gyrus and left insular lobe. No increased gray matter volume was apparent. These data indicate that gray matter atrophy in the limbic system and cerebral neocortex is related to the presence of dementia.