中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (18): 1637-1643.doi: 10.3969/j.issn.1673-5374.2013.18.001

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传统中药丹皮酚抑制炎症介导的神经毒性

  

  • 收稿日期:2012-11-19 修回日期:2013-03-13 出版日期:2013-06-25 发布日期:2013-06-25

Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation

Kyong Nyon Nam1, Byung-Cheol Woo2, Sang-Kwan Moon2, Seong-Uk Park2, Joo-young Park2, Jae-Woong Hwang2, Hyung-Sup Bae2, Chang-Nam Ko2, Eunjoo Hwang Lee1   

  1. 1 Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 446-701, Republic of Korea
    2 Department of Cardiovascular & Neurologic Diseases (Stroke Center), Hospital of Oriental Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea
  • Received:2012-11-19 Revised:2013-03-13 Online:2013-06-25 Published:2013-06-25
  • Contact: Eunjoo Hwang Lee, Ph.D., Professor, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 446-701, Republic of Korea, ehwang@khu.ac.kr
  • About author:Kyong Hyon Nam☆, Ph.D., Post-doctoral Fellow, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 446-701, Republic of Korea Kyong Nyon Nam and Byung-Cheol Woo contributed equally to this work.

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摘要：

小胶质细胞的激活通过释放多种促炎和神经毒性因子，对神经元的存活造成威胁。提取自毛茛科植物牡丹的干燥根皮的丹皮酚有抗氧化、抗炎和神经保护作用。为了解丹皮酚对炎症诱导的神经毒性和小胶质细胞激活的抑制效应。我们用脂多糖刺激大鼠大脑海马脑片和原代培养的小胶质细胞。在进行脂多糖刺激前，先以丹皮酚干预30min。结果发现：（1）在海马脑片中，丹皮酚抑制脂多糖诱导的海马细胞死亡和一氧化氮产物和白细胞介素1β的释放。（2）在小胶质细胞中，丹皮酚抑制脂多糖诱导的小胶质细胞释放一氧化氮、肿瘤坏死因子α和白细胞介素1β。结果说明丹皮酚能对炎症诱导的神经毒性产生抑制效应。

关键词: 神经再生, 中医药, 炎症, 丹皮酚, 炎症介质, 小胶质细胞, 神经毒性, 神经保护, 海马脑片