中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (24): 2284-2289.doi: 10.3969/j.issn.1673-5374.2013.24.008

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

内耳再生：过去到现在

  

  • 收稿日期:2013-03-15 修回日期:2013-05-10 出版日期:2013-08-25 发布日期:2013-08-25

Inner ear hair cell regeneration A look from the past to the future

Francisco Santaolalla1, 2, Carlos Salvador1, Agustín Martínez2, Jose María Sánchez2, Ana Sánchez del Rey2   

  1. 1 Department of Otorhinolaryngology, Basurto University Hospital, Bilbao, Bizkaia, Spain
    2 Department of Dermatology, Ophthalmology and Otorhinolaryngology, School of Medicine, University of the Basque Country (UPV/EHU), Bilbao, Bizkaia, Spain
  • Received:2013-03-15 Revised:2013-05-10 Online:2013-08-25 Published:2013-08-25
  • Contact: Francisco Santaolalla, M.D. Department of Otorhinolaryngology, Basurto University Hospital, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), Gurtubay, s/n, 48013 Bilbao, Spain, francisco.santaolalla@ehu.es.

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摘要：

目前，涉及内耳毛细胞再生的研究主要包括干细胞、基因疗法、神经营养因子等方面。耳蜗基因疗法在治疗神经性听力损失方面已取得成功。文章旨在分析和综述内耳毛细胞再生相关研究和应用的进展情况。

关键词: 神经再生, 综述, 听力损伤, 听力, 再生, 毛细胞, 耳蜗, 基因, 病毒载体, 干细胞

Abstract:

Most recent studies on regeneration of inner ear hair cells focus on use of stem cells, gene therapy and neurotrophic factors. Cochlear gene therapy has been successfully used in the treatment of neu-rosensory hearing loss. This suggests that cochlear hair cell regeneration is possible. The objective of this paper is to review research and clinical application of inner near hair cell regeneration.

Key words: neural regeneration, reviews, hearing loss, hair cells, cochlea, genes, stem cells, viral vectors, re-generation, neuroregeneration