中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2013, Vol. 8 ›› Issue (32): 3055-3062.doi: 10.3969/j.issn.1673-5374.2013.32.009

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

以黏弹性评价胎儿脐静脉移植重建大脑中动脉

  

  • 收稿日期:2013-04-22 修回日期:2013-07-23 出版日期:2013-11-15 发布日期:2013-11-15

Viscoelastic evaluation of fetal umbilical vein for reconstruction of middle cerebral artery

Dongyuan Li1, Donghui Xu1, Peng Li2, Jun Wei1, Kun Yang3, Conghai Zhao1   

  1. 1 Department of Neurosurgery, China-Japan Friendship Hospital, Jilin University, Changchun 130031, Jilin Province, China
    2 Department of Engineering Mechanics, Nanling Branch, Jilin University, Changchun 130022, Jilin Province, China
    3 Basic Department, Air Force Aviation University, Changchun 130022, Jilin Province, China
  • Received:2013-04-22 Revised:2013-07-23 Online:2013-11-15 Published:2013-11-15
  • Contact: Conghai Zhao, Ph.D., Professor, Department of Neurosurgery, China-Japan Friendship Hospital, Jilin University, Changchun 130031, Jilin Province, China, shm753@sina.com.
  • About author:Dongyuan Li, Ph.D., Associate professor.

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摘要：

内径小于6mm人工血管替代人体小动脉或静脉移植一直未获得满意的效果，已有研究将脐带静脉作为动脉用于血管移植，但两者之间的应力松弛和蠕变等重要黏弹性特性指标是否一致尚需明确。为此实验取自然分娩胎儿脐静脉和成年男性尸体的大脑中动脉，制成长15mm、中膜厚0.196-0.268mm、外径为2.82-2.96mm的试样，进行的应力松驰和蠕变实验结果表明，无论是施加18.7kPa还是22.5kPa初始应力，大脑中动脉试样与胎儿脐静脉试样在7200s应力时下降量接近，而胎儿脐静脉试样在7200s应变上升量大于大脑中动脉试样，且施加初始应力22.5kPa应力时，2组试样松弛实验7200s下降量小于施加初始应力18.7kPa时。说明胎儿脐静脉具有很好的应力松弛特性和蠕变特性，这种特性有利于将胎儿脐静脉移植用于损伤大脑中动脉的血管重建。

关键词: 神经再生, 神经可塑性, 大脑中动脉, 胎儿脐静脉, 应力松弛特性, 蠕变特性, 黏弹性, 移植, 生物材料, 生物力学

Abstract:

The transplantation of artificial blood vessels with < 6 mm inner diameter as substitutes for human arterioles or veins has not achieved satisfactory results. Umbilical vein has been substituted for ar-tery in vascular transplantation, but it remains unclear whether the stress relaxation and creep be-tween these vessels are consistent. In this study, we used the fetal umbilical vein and middle cere-bral artery from adult male cadavers to make specimens 15 mm in length, 0.196–0.268 mm in tu-nica media thickness, and 2.82–2.96 mm in outer diameter. The results demonstrated that the stress decrease at 7 200 seconds was similar between the middle cerebral artery and fetal umbilical vein specimens, regardless of initial stress of 18.7 kPa or 22.5 kPa. However, the strain increase at 7 200 seconds of fetal umbilical veins was larger than that of middle cerebral arteries. Moreover, the stress relaxation experiment showed that the stress decrease at 7 200 seconds of the fetal umbilical vein and middle cerebral artery specimens under 22.5 kPa initial stress was less than the decrease in these specimens under 18.7 kPa initial stress. These results indicate that the fetal umbilical vein has appropriate stress relaxation and creep properties for transplantation. These properties are advantageous for vascular reconstruction, indicating that the fetal umbilical vein can be transplanted to repair middle cerebral artery injury.