中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (5): 489-497.doi: 10.4103/1673-5374.130067

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

舒肝解郁胶囊增加抑郁大鼠脑内神经营养因子的表达

  

  • 收稿日期:2014-02-22 出版日期:2014-03-12 发布日期:2014-03-12
  • 基金资助:

    国家自然科学基金项目(No. 81071093，81171268)

Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression

Jinhua Fu 1, 2, Yingjin Zhang 3, Renrong Wu 1, Yingjun Zheng 4, Xianghui Zhang 1, Mei Yang 2, Jingping Zhao 1, Yong Liu 1   

  1. 1 Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South
    University, Changsha, Hunan Province, China
    2 Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan Province, China
    3 Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
    4 Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, China
  • Received:2014-02-22 Online:2014-03-12 Published:2014-03-12
  • Contact: Jingping Zhao, M.D., Ph.D., Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, Hunan Province, China, zhaojingpingcsu@163.com. Yong Liu, Ph.D., Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, Hunan Province, China, csuliuyong@163.com.

PDF

2005

摘要：

舒肝解郁胶囊2008年被中国食药监局批准进入临床治疗轻中度抑郁。实验建立了抑郁模型，每天应激前给舒肝解郁胶囊灌胃治疗。行为学结果证实高剂量(150 mg/kg)舒肝解郁胶囊治疗的抑郁大鼠抑郁症状减轻。免疫组化染色显示，经高剂量舒肝解郁胶囊治疗的抑郁大鼠内侧前额皮质和海马CA3区脑源性神经营养因子和磷酸化环磷酸腺苷反应蛋白结合元件的表达增加，表明舒肝解郁胶囊能通过弥补抑郁大鼠脑内神经营养因子缺陷而改善抑郁行为。

关键词: 神经再生, 舒肝解郁胶囊, 抑郁, 神经营养因子, 脑源性神经营养因子, 磷酸化环磷酸腺苷反应蛋白结合元件, 慢性轻度不可预见性应激, NSFC grant

Abstract:

Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose (150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain.

Key words: nerve regeneration, Shuganjieyu capsule, depression, neurotrophic factor, brain-derived neurotrophic factor, phosphorylation cyclic adenosine monophosphate response element binding protein, chronic unpredictable mild stress, NSFC grant, neural regeneration

中图分类号: