中国神经再生研究(英文版)

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

慢性脑卒中运动皮质区神经元损伤与下肢功能缺损:基于体素的病灶-症状图研究

  

  • 收稿日期:2014-03-10 出版日期:2014-04-15 发布日期:2014-04-15
  • 基金资助:

    USC McCausland大脑影像中心基金

Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study

Alexandria M. Reynolds 1, Denise M. Peters 2, Jennifer M. C. Vendemia 3, Lenwood P. Smith 4, Raymond C. Sweet 4, Gordon C. Baylis 5, Debra Krotish 6, Stacy L. Fritz 2   

  1. 1 Department of Psychology, Barnwell College, University of South Carolina, Columbia, SC, USA
    2 Department of Exercise Science, University of South Carolina, Columbia, SC, USA
    3 Department of Psychology, University of South Carolina, Columbia, SC, USA
    4 Neurosurgery Center, University of South Carolina School of Medicine, Columbia, SC, USA
    5 Western Kentucky University, Bowling Green, KY, USA
    6 University of South Carolina School of Medicine, Columbia, SC, USA
  • Received:2014-03-10 Online:2014-04-15 Published:2014-04-15
  • Contact: Alexandria M. Reynolds, M.A., 1512 Pendleton Street, Department of Psychology, Barnwell College, University of South Carolina, Columbia, SC 29208 USA, cooleyam@gmail.com.
  • Supported by:

    This work was supported by intramural funding from the University of South Carolina McCausland Center for Brain Imaging.

关键词: 神经再生, MRI, 脑卒中, 大脑皮质, 运动皮质系统, 基于体素的病灶-症状图;运动功能, 预后

Abstract:

Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.