中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (12): 1210-1216.doi: 10.4103/1673-5374.135329

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

自噬:脑缺血性损伤后神经元存活的双刃剑

  

  • 出版日期:2014-06-24 发布日期:2014-06-24

Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

Wenqi Chen 1, Yinyi Sun 1, Kangyong Liu 2, Xiaojiang Sun 1   

  1. 1 Department of Neurology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
    2 Zhoupu Hospital, Pudong New District, Shanghai, China
  • Online:2014-06-24 Published:2014-06-24
  • Contact: Xiaojiang Sun, Department of Neurology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China, sunxj155@sohu.com. Kangyong Liu, Zhoupu Hospital, Pudong New District, Shanghai, China, liukangyong555@aliyun.com.

摘要:

有研究表明,自噬可能是脑卒中治疗的新靶点,激活自噬可能降低脑缺血损伤的神经元死亡率,但这一观点尚未达成共识。文章综述了自噬对脑缺血损伤后神经元存活的潜在作用及可能的信号通路,提出了自噬在脑缺血性损伤后对神经元存活有双重作用。
 

关键词: 神经再生, 自噬, 蛋白酶体, 自噬体, 神经元, 脑缺血, 信号通路, 凋亡, 坏死, 存活, 文献综述

Abstract:

Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.

Key words: nerve regeneration, autophagy, lysosome, autophagosome, neuron, cerebral ischemia, signaling pathway, apoptosis, necrosis, survival, NSFC grant, neural regeneration