中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (15): 1464-1473.doi: 10.4103/1673-5374.139464

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

不同时程应应激处理下动物行为结果的整合

  

  • 收稿日期:2014-06-19 出版日期:2014-08-12 发布日期:2014-08-12
  • 基金资助:

    国家自然科学基金项目(30971057);中科院知识创新工作重要方向项目(KSCX2-EW-J-8)

Integration of animal behaviors under stresses with different time courses

Lun Zheng 1, Xigeng Zheng 2   

  1. 1 Key Laboratory of Mental Health, Chinese Academy of Sciences, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    2 Graduate School, Chinese Academy of Sciences, Beijing, China
  • Received:2014-06-19 Online:2014-08-12 Published:2014-08-12
  • Contact: Lun Zheng, Key Laboratory of Mental Health, Chinese Academy of Sciences, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China, zhengluntj@163.com.
  • Supported by:

    nerve regeneration; brain injury; depression; stress resistance; susceptible to depression;    chronic unpredictable stress; forced swim; dopamine; nucleus accumbens; NSFC grant; neural regeneration

摘要:

实验采用 “急性强迫游泳”动物模型以及“慢性不确定性应激”动物模型,希望揭示在急性强迫游泳处理下高漂浮行为的被动应对方式对于慢性不确定性应激处理后的快感缺失行为是否具有预测作用,以及多巴胺系统对于漂浮行为和快感缺失行为是否具有调节作用?结果发现,在急性强迫游泳处理下以“漂浮行为”作为应对方式的抑郁易感大鼠在随后的慢性不确定性应激处理下更容易出现快感缺失,腹腔注射或伏核微量注射多巴胺2,3受体亚型激动剂ropinirole均可以降低抑郁易感动物的漂浮行为,升高快感缺失大鼠的糖水偏爱值。说明漂浮行为作为一种被动防御方式是易感个体在急性应激下倾向于采用的防御应对方式,同时这类动物在长期应激处理下更容易出现快感缺失,即更有可能发展为抑郁;而伏核多巴胺2,3受体亚型在漂浮行为和快感缺失中发挥重要作用。。

Abstract:

We used animal models of “forced swim stress” and “chronic unpredictable stress”, and tried to reveal whether a passive coping style of high flotation behavior in forced swim stress predicts anhedonia behavior after chronic unpredictable stress, and whether the dopamine system regulates floating and anhedonia behaviors. Our results confirmed that depression-prone rats use “floating behavior” as a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress. Intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. These data indicate that floating behavior is a defensive mode that is preferred by susceptible individuals under conditions of acute stress. Simultaneously, these animals more readily experienced anhedonia under long-term stress; that is, they were more readily affected by depression. Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia.

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