中国神经再生研究(英文版) ›› 2014, Vol. 9 ›› Issue (22): 2008-2012.doi: 10.4103/1673-5374.143436

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤动物模型的建立和评估

  

  • 收稿日期:2014-09-08 出版日期:2014-11-25 发布日期:2014-11-25

Evaluation of spinal cord injury animal models

Ning Zhang 1, Marong Fang 2, Haohao Chen 1, Fangming Gou 1, Mingxing Ding 1, 2   

  1. 1 Department of Medical Sciences, Jinhua Polytechnic, Jinhua, Zhejiang Province, China
    2 Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
  • Received:2014-09-08 Online:2014-11-25 Published:2014-11-25
  • Contact: Mingxing Ding, Department of Medical Sciences, Jinhua Polytechnic, Jinhua 321007, Zhejiang Province, China; Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China, mxding@hotmail.com.

摘要:

建立操作具可重复性、贴近临床实际的脊髓损伤动物模型是研究脊髓损伤机制、寻找促进损伤脊髓修复策略的基础。文章综述和分析了多种脊髓损伤动物模型,并评估用于脊髓损伤研究的优缺点。

关键词: 神经再生, 脊髓损伤, 动物模型, 建立, 评估, 综述

Abstract:

Because there is no curative treatment for spinal cord injury, establishing an ideal animal model is important to identify injury mechanisms and develop therapies for individuals suffering from spinal cord injuries. In this article, we systematically review and analyze various kinds of animal models of spinal cord injury and assess their advantages and disadvantages for further studies.

Key words: nerve regeneration, spinal cord injury, animal model, establishment, evaluation, reviews, neural regeneration