中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (4): 659-666.doi: 10.4103/1673-5374.155444

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

连接蛋白或可成为保护中枢神经系统的潜在治疗新靶点?

  

  • 收稿日期:2014-11-20 出版日期:2015-04-22 发布日期:2015-04-22
  • 基金资助:

    国家自然科学基金面上项目(81271293),国家青年科学家科学基金(81000490)

Connexin: a potential novel target for protecting the central nervous system?

Hong-yan Xie 1, Yu Cui 2, Fang Deng 1,  Jia-chun Feng 1   

  1. 1 Departmet of Neurology, the First Hospital of Jilin University, Changchun, Jilin Province, China
    2 Department of Neurosurgery, the First People’s Hospital of Xianyang, Xianyang, Shaanxi Province, China
  • Received:2014-11-20 Online:2015-04-22 Published:2015-04-22
  • Contact: Jia-chun Feng or Fang Deng, clinicalted@gmail.com or defrances2000@163.com.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (General Program), No. 81271293 and the National Science Foundation for Young Scientists of China,        No. 81000490.

摘要:

连接蛋白被广泛认可的功能是形成缝隙连接通道,介导相邻细胞之间离子、小分子营养物质交换及信号分子传导。文章在讨论连接蛋白/半通道/缝隙连接在生理条件下功能的同时,重点综述其在脑缺血、创伤性脑和脊髓损伤、癫痫、脑和脊髓肿瘤、偏头痛、神经自身免疫疾病、阿尔茨海默病、帕金森病、X-连锁遗传的腓骨肌萎缩症、佩梅样病、痉挛性截瘫、颌面部发育不良这些中枢神经系统疾病病理生理机制中作用的研究进展,并认为连接蛋白可能是中枢神经系统疾病治疗的潜在干预靶点。

关键词: connexin, 缝隙连接, 生物合成通路, 生物降解, 大脑, 中枢神经系统

Abstract:

Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings regarding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer’s disease, Parkinson’s disease, X-linked Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.

Key words: connexin, gap junction, biosynthetic pathways, biodegradation, brain, central nervous system diseases