中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (9): 1418-1420.doi: 10.4103/1673-5374.165509

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

神经元兴奋性的“刹车”:吡罗昔康以调节5-羟色胺而保护缺血性脑卒中

  

  • 收稿日期:2015-07-01 出版日期:2015-09-28 发布日期:2015-09-28

Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a “brake” on neuronal excitability in ischemic stroke

Pallab Bhattacharya1, 2, Anand Kumar Pandey2, Sudip Paul2, 3, Ranjana Patnaik2   

  1. 1 Department of Neurology, Leonard M. Miller School of Medicine, Miami, FL, USA
    2 School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India
    3 Department of Biomedical Engineering, North Eastern Hill University (NEHU), Shillong, India
  • Received:2015-07-01 Online:2015-09-28 Published:2015-09-28
  • Contact: Pallab Bhattacharya, Ph.D., or Ranjana Patnaik, Ph.D., p.bhattacharya@med.miami.edu or drranjanapatnaik@gmail.com.

摘要:

吡罗昔康给药会缓解脑缺血啮齿类动物模型中谷氨酸介导的兴奋性毒性,并使细胞外激动γ-氨基丁酸的增加。该篇研究是一个合乎逻辑的延伸,主要探讨激动γ-氨基丁酸是否由吡罗昔康影响外五羟色胺。脑皮层和纹状体高效液相色谱法表明,吡罗昔康预处理大鼠大脑脑皮层和纹状体的细胞外血清素释放显著跌幅。这个线索表明吡罗昔康在缺血性脑冲击中减少外羟色胺外排作用可能是由于吡罗昔康激动γ-氨基丁酸带来的。

关键词: 神经再生, 神经保护, 缺血性脑卒中, 5-羟色胺, γ-氨基丁酸, γ-氨基丁酸A受体, 大脑皮质, 纹状体

Abstract:

Our previous studies indicated an increase in extracellular γ-aminobutyric acid (GABA) in rodent’s ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor (GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam.