中国神经再生研究(英文版) ›› 2015, Vol. 10 ›› Issue (11): 1882-1891.doi: 10.4103/1673-5374.170324

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

大脑微血管内皮细胞可成为脑卒中神经保护的干预靶点?

  

  • 收稿日期:2015-07-08 出版日期:2015-12-07 发布日期:2015-12-07
  • 基金资助:

    国家自然科学基金81171112, 81371272

Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke

Qi-jin Yu1, *, Hong Tao1, Xin Wang2, Ming-chang Li3, *   

  1. 1 Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
    2 Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
    3 Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
  • Received:2015-07-08 Online:2015-12-07 Published:2015-12-07
  • Contact: Qi-jin Yu, M.D., Ph.D. or Ming-chang Li, M.D., Ph.D., yqj2566@sina.com or whulmc@126.com.
  • Supported by:

    This work was supported by grants from the National Natural Science Foundation of China, No. 81171112, 81371272 to MCL.

摘要:

大脑微血管内皮细胞有调节中枢神经系统内稳态的作用,其与周围内皮细胞在离子转运体、受体表达方面有所不同。大脑微血管内皮细胞还能合成一些影响血管功能的因子。文章综述了大脑微血管内皮细胞的形态特征及其在脑卒中病程和治疗中的作用,展示了大脑微血管内皮细胞作为脑卒中神经保护干预靶点的潜力。

关键词: 神经再生, 神经保护, 脑卒中, 血脑屏障, 大脑微血管内皮细胞, 内皮素, 血栓烷A2

Abstract:

Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression of specific ion transporters and receptors, and contain fewer fenestrations and pinocytotic vesicles. Brain microvascular endothelial cells also synthesize several factors that influence blood vessel function. This review describes the morphological characteristics and functions of brain microvascular endothelial cells, and summarizes current knowledge regarding changes in brain microvascular endothelial cells during stroke progression and therapies. Future studies should focus on identifying mechanisms underlying such changes and developing possible neuroprotective therapeutic interventions.

Key words: nerve regeneration, blood-brain barrier, brain microvascular endothelial cells, cerebral infarction, subarachnoid hemorrhage, gap junction, endothelin, thromboxane A2, neural regeneration