中国神经再生研究(英文版) ›› 2016, Vol. 11 ›› Issue (5): 835-841.doi: 10.4103/1673-5374.182713

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

甲基泼尼松龙纳米微球缓释膜抑制周围神经断端瘢痕的形成

  

  • 收稿日期:2015-12-22 出版日期:2016-05-20 发布日期:2016-05-20
  • 基金资助:

    漳州市科技基金(Z2010086)

Methylprednisolone microsphere sustained-release membrane inhibits scar formation at the site of peripheral nerve lesion

Qiang Li #, Teng Li #, Xiang-chang Cao, De-qing Luo, Ke-jian Lian*   

  1. The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, Fujian Province, China
  • Received:2015-12-22 Online:2016-05-20 Published:2016-05-20
  • Contact: Ke-jian Lian, gkxiaohe@163.com.
  • Supported by:

    This study was supported by the Technology Fund of Zhangzhou City in China, No. Z2010086.

摘要:

目前糖皮质激素被广泛应用于急性中枢神经系统损伤,但糖皮质激素半衰期较短,作用时间短,若能实现糖皮质激素逐渐释放至神经断端,将延长糖皮质激素的作用时间,可能更好地实现抑制瘢痕的形成。鉴于此,实验将甲基泼尼松龙结合在纳米微球上,制作成载甲基泼尼松龙纳米微球缓释膜,包裹于大鼠坐骨神经断端吻合口处,以期达到更好的修复效果。结果发现与单独甲基泼尼松龙或纳米微球治疗的坐骨神经损伤大鼠相比,载甲基泼尼松龙纳米微球缓释膜组神经吻合口可见轻度组织黏连,神经吻合口瘢痕组织减少,坐骨神经功能指数及髓鞘厚度均增加,说明载甲基泼尼松龙纳米微球缓释膜能有效抑制周围神经吻合口的瘢痕形成,促进神经再生。

orcid: 0000-0001-7030-8009(Ke-jian Lian)

关键词: 神经再生, 周围神经损伤, 纳米, 瘢痕, 甲基泼尼松龙, 缓释膜, 生物防黏剂, 周围神经

Abstract:

"Corticosteroids are widely used for the treatment of acute central nervous system injury. However, their bioactivity is limited by their short half-life. Sustained release of glucocorticoids can prolong their efficacy and inhibit scar formation at the site of nerve injury. In the present study, we wrapped the anastomotic ends of the rat sciatic nerve with a methylprednisolone sustained-release membrane. Compared with methylprednisone alone or methylprednisone microspheres, the methylprednisolone microsphere sustained-release membrane reduced tissue adhesion and inhibited scar tissue formation at the site of anastomosis. It also increased sciatic nerve function index and the thickness of the myelin sheath. Our findings show that the methylprednisolone microsphere sustained-release membrane effectively inhibits scar formation at the site of anastomosis of the peripheral nerve, thereby promoting nerve regeneration."

Key words: nerve regeneration, peripheral nerve injury, nanometer, scar, methylprenisolone, sustained-release membrane, biological agents, peripheral nerve, neural regeneration