中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (2): 388-393.doi: 10.4103/1673-5374.290912

• 原著:视神经损伤修复保护与再生 • 上一篇    下一篇

静息态功能磁共振成像可见推拿仪治疗周围神经损伤后大脑的可塑性变化

  

  • 出版日期:2021-02-15 发布日期:2020-12-04
  • 基金资助:

    国家重点研发计划项目(2018YFC2001600);上海市科学技术委员会项目(185111083001841190380018441903900

Brain plasticity after peripheral nerve injury treatment with massage therapy based on resting-state functional magnetic resonance imaging

Xiang-Xin Xing1, 2, #, Mou-Xiong Zheng3, #, Xu-Yun Hua3, 4, #, Shu-Jie Ma1, Zhen-Zhen Ma1, Jian-Guang Xu1, *#br#   

  1. 1 School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China;  2 Department of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;  3 Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;  4 Yangzi Rehabilitation Hospital, Tongji University, Shanghai, China
  • Online:2021-02-15 Published:2020-12-04
  • Contact: Jian-Guang Xu, MD, PhD, xjg@shutcm.edu.cn. #These authors contributed equally to this work.
  • Supported by:
    This study was supported by National Key R&D Program of China, No. 2018YFC2001600 (to JGX); and Shanghai Science and Technology Committee of China, Nos. 18511108300 (to JGX), 18441903800 (to MXZ) and 18441903900 (to XYH).

摘要:

推拿疗法是一种可能治疗与大脑可塑性有关的慢性疼痛的替代疗法,但其潜在机制尚不清楚。实验通过单侧坐骨神经横断并直接吻合建立周围神经损伤大鼠模型,以专利定制推拿仪对大鼠右侧腓肠肌进行推拿,强度0.45N,120次/min,每次10min,1次/d,连续4周。静息态功能磁共振成像结果显示,与正常大鼠相比,坐骨神经横断后,大鼠患肢对侧大脑感觉运动皮质低频波动幅度明显降低;而经推拿后低频波动幅度明显恢复,且高于假推拿组。结果表明推拿可促进体感皮质的适应性变化,并促进周围神经损伤和修复。该研究于2017年1月12日获得中国上海中医药大学动物伦理委员会批准(批准号201701001)。

https://orcid.org/0000-0003-0601-3403 (Jian-Guang Xu)

关键词: 周围神经, 神经元, 模型, 大鼠, 可塑性, 推拿, 损伤, 修复

Abstract: Massage therapy is an alternative treatment for chronic pain that is potentially related to brain plasticity. However, the underlying mechanism remains unclear. We established a peripheral nerve injury model in rats by unilateral sciatic nerve transection and direct anastomosis. The experimental rats were treated over the gastrocnemius muscle of the affected hindlimb with a customized massage instrument (0.45 N, 120 times/min, 10 minutes daily, for 4 successive weeks). Resting-state functional magnetic resonance imaging revealed that compared with control rats, the amplitude of low-frequency fluctuations in the sensorimotor cortex contralateral to the affected limb was significantly lower after sciatic nerve transection. However, amplitudes were significantly higher in the massage group than in a sham-massage group. These findings suggest that massage therapy facilitated adaptive change in the somatosensory cortex that led to the recovery of peripheral nerve injury and repair. This study was approved by the Animal Ethics Committee of Shanghai University of Traditional Chinese Medicine of China (approval No. 201701001) on January 12, 2017.

Key words: injury, massage, model, neuron, peripheral nerve, plasticity, rat, repair