关键词: 神经再生, 微泡, 淀粉样&beta, 蛋白, tau, 炎症反应, 氧化应激, 干预靶点, 神经退行性疾病, 老年痴呆

Abstract:

Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as multivesicular bodies. Thus, exosomes contain cytoplasmic content. Multivesicular bodies fuse with the plasma membrane and release exosomes into the extracellular environment. Comprehensive research suggests that exosomes act as both inflammatory intermediaries and critical inducers of oxidative stress to drive progression of Alzheimer’s disease. An important role of exosomes in Alzheimer’s disease includes the formation of neurofibrillary tangles and beta-amyloid production, clearance, and accumulation. In addition, exosomes are involved in neuroinflammation and oxidative stress, which both act as triggers for beta-amyloid pathogenesis and tau hyperphosphorylation. Further, it has been shown that exosomes are strongly associated with beta-amyloid clearance. Thus, effective measures for regulating exosome metabolism may be novel drug targets for Alzheimer’s disease.

Key words: nerve regeneration, microvesicle, beta-amyloid, tau, neuroinflammation, oxidative stress, therapeutic target, neurodegeneration, dementia, neural regeneration