中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (1): 51-58.doi: 10.4103/1673-5374.243701

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

应用组织工程方法修复周围神经损伤

  

  • 出版日期:2019-01-15 发布日期:2019-01-15
  • 基金资助:

    国家自然科学基金(31040043,81171146,81372044,30971526, 31771322, 31571235, 51373023, 21171019, 31640045, 31771236, 31471144, 31100860, 31371210); 中国国家科技部973项目,编(2014CB542201); 中国教育部创新团队(IRT1201); 北京大学健康科学中心培养青年学者(BMU2017PY013); 北京市科技新星交叉项目(2018019)

Tissue engineering for the repair of peripheral nerve injury

Pei-Xun Zhang1, Na Han1, Yu-Hui Kou1, Qing-Tang Zhu2, Xiao-Lin Liu2, Da-Ping Quan2, Jian-Guo Chen3, Bao-Guo Jiang1   

  1. 1 Peking University People’s Hospital, Beijing, China;
    2 The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China;
    3 School of Life Science, Peking University, Beijing, China
  • Online:2019-01-15 Published:2019-01-15
  • Contact: Bao-Guo Jiang, MD, PhD, jiangbaoguo@vip.sina.com; Na Han, PhD, 876804705@qq.com
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 31040043, 31671248 (to NH), No. 81171146, 81372044, 30971526 (to BGJ); the Chinese National Ministry of Science and Technology (973 Project), No. 2014CB542201 (to PXZ); the Min-istry of Education Innovation Team, China, No. IRT1201 (to PXZ); the Fostering Young Scholars of Peking University Health Science Center, China, No. BMU2017PY013 (to PXZ); the Chinese National General Program of National Natural Science Fund, China (to PXZ); the Beijing City Science & Technology New Star Cross Project, China, No. 2018019 (to PXZ); the National Natural Science Foundation of China, No. 31771322, 31571235, 51373023, 21171019, 31640045, 31571236, 31471144, 31100860, 31371210 (to PXZ).

摘要:

周围神经损伤是一种常见的临床问题,影响患者的生活质量。传统修复方法的效果并不令人满意,因此越来越多的研究人员将目光投向组织工程领域。生物支架材料、种子细胞和各种生长因子是建立神经组织工程的3个关键点。为修复周围神经损伤,促进周围神经再生,应了解神经损伤的类型,支架的构建及修复过程。文章描述了周围神经损伤的类型、周围神经组织工程的研究进展和周围神经支架材料的临床研究情况,以期为相关研究的开展铺平道路。

orcid: 0000-0001-8436-5266(Bao-Guo Jiang)
           0000-0001-9585-3732 (Na Han)

关键词: 神经导管, 支架, 生物材料, 干细胞, 神经生长因子, 周围神经损伤, 周围神经修复, 组织工程, 神经再生

Abstract:

Peripheral nerve injury is a common clinical problem and affects the quality of life of patients. Traditional restoration methods are not satisfactory. Researchers increasingly focus on the field of tissue engineering. The three key points in establishing a tissue engineering material are the biological scaffold material, the seed cells and various growth factors. Understanding the type of nerve injury, the construction of scaffold and the process of repair are necessary to solve peripheral nerve injury and promote its regeneration. This review describes the categories of peripheral nerve injury, fundamental research of peripheral nervous tissue engineering and clinical research on peripheral nerve scaffold material, and paves a way for related research and the use of conduits in clinical practice.

Key words: nerve regeneration, scaffold, biomaterial, stem cells, nerve growth factor, peripheral nerve injury, peripheral nerve repair, tissue engineering, neural regeneration