中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (8): 1352-1363.doi: 10.4103/1673-5374.253512

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

再生生物材料在脊髓损伤修复中的作用及前景

  

  • 出版日期:2019-08-15 发布日期:2019-08-15
  • 基金资助:

    国家自然科学基金(81571213,81800583)、江苏省第13次6届人才高峰项目、南京医学科技发展基金(QRX17006)和南京医学科学与创新平台(ZDX16005)

Role and prospects of regenerative biomaterials in the repair of spinal cord injury

Shuo Liu, Yuan-Yuan Xie, Bin Wang   

  1. Clinical Stem Cell Center, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province,  China
  • Online:2019-08-15 Published:2019-08-15
  • Contact: Bin Wang, MD, wangbin022800@126.com.
  • Supported by:

    This work was supported by the National Natural Science Foundation of China, No. 81571213 (to BW), No. 81800583 (to YYX); the 13 th Six Talent Peaks Project (C type) of Jiangsu Province of China (to BW); the Medical Science and Technique Development Foundation of Nanjing of China, No. QRX17006 (to BW); and the Medical Science and Innovation Platform of Nanjing of China, No. ZDX16005 (to BW).

摘要:

脊髓损伤后轴突被破坏以及形成的抑制环境会严重阻碍损伤组织和神经功能的再生。在脊髓损伤部位,再生生物材料可以填充空腔,释放药物,为移植或宿主细胞提供吸附位点。此外,一些再生生物材料还能抑制细胞凋亡,抑制炎症和胶质瘢痕形成,进一步促进神经发生、轴突生长和血管生成。文章综述了应用于脊髓损伤修复过程中的多种再生生物材料的研究进展。虽然许多天然和合成再生生物材料支架在脊髓损伤修复中已经显示出一定的治疗效果,但仍有许多问题需要解决,如其产品标准和材料的安全性和有效性等问题。

orcid: 0000-0003-3981-8849 (Bin Wang)

关键词: 脊髓损伤, 再生生物材料, 支架, 组织工程, 再生, 移植, 组合, 功能恢复, 修复策略, 微环境

Abstract:

Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regener¬ation of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some re¬generative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.

Key words: nerve regeneration, spinal cord injury, regenerative biomaterials, scaffolds, tissue engineering, regeneration, transplantation, combination, functional recovery, repair strategy, microenvironment, neural regeneration