中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (9): 1494-1498.doi: 10.4103/1673-5374.255960

• 综述:退行性病与再生 • 上一篇    下一篇

青蒿素不仅抗疟还具有治疗神经退行性疾病的潜力

  

  • 出版日期:2019-09-15 发布日期:2019-09-15
  • 基金资助:

    北京市自然科学基金项目（7192235）

More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration

Bing-Wen Lu 1, 2 , Larry Baum 3, 4, 5 , Kwok-Fai So 2, 3, 4, 6 , Kin Chiu 2, 3 , Li-Ke Xie 1   

  1. 1 Department of Ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China
    2 Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administration Region, China
    3 State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong Special Administration Region, China
    4 Center for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong Special Administration Region, China
    5 Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong Special Administration Region, China
    6 GHM Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China
  • Online:2019-09-15 Published:2019-09-15
  • Contact: Li-Ke Xie, MD, bjxielike@sina.com; Kin Chiu, PhD, datwai@hku.hk.
  • Supported by:

    This work was supported by the Natural Science Foundation of Beijing of China, No. 7192235 (to LKX).

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摘要：

青蒿素源于中国传统药用植物青蒿。青蒿素及其衍生物已被作为抗疟药广泛使用多年，且几乎没有不良反应。最近有证据表明，青蒿素可能对疟疾以外的其他疾病有治疗价值，这些疾病包括癌症、炎症性疾病和自身免疫性疾病等。神经退行性变是一种年龄相关的神经疾病，其特征为神经元结构和功能的退化，而神经炎症被认为是阿尔茨海默病等多种神经退行性疾病发展的潜在因素。研究发现，青蒿素可能通过减少氧化、炎症和Aβ来治疗神经退行性疾病。此次综述将介绍青蒿素在神经保护方面作用及可能机制。文章将展示青蒿素在神经退行性疾病治疗中的潜力。

orcid: 0000-0001-6581-9007 (Kin Chiu)
          0000-0001-5877-6459 (Bing-Wen Lu)

关键词: 青蒿素, 炎症, 神经炎症, 神经退行性疾病, 阿尔茨海默病, 帕金森病, A&beta, 抗氧化, 神经保护, 神经再生

Abstract:

Artemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant (Artemisia annua), which is used in traditional Chinese medicine. Artemisinin and its derivatives (artemisinins) have been widely used for many years as anti-malarial agents, with few adverse side effects. Interestingly, evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria, including cancers, inflammatory diseases, and autoimmune disorders. Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions, whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders, including Alzheimer’s disease. Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation, inflammation, and amyloid beta protein (Aβ). In this review, we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities, suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders.

Key words: artemisinin, inflammation, neuroinflammation, neurodegeneration, Alzheimer’s disease, Parkinson’s disease, Aβ, anti-oxidation, neuroprotection, neural regeneration