中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (3): 643-648.doi: 10.4103/1673-5374.320994

• 原著:脑损伤修复保护与再生 • 上一篇    下一篇

日常生活活动能力受限会增加中国老年脑卒中的风险：基于人口学的纵向研究

  

  • 出版日期:2022-03-15 发布日期:2021-10-15

Limitations in activities of daily living increase the risk of stroke in older Chinese adults: a population-based longitudinal study

Zhuang-Sheng Wei1, #, Yu-Sen Chen1, #, Ying Wu1, Chen-Yao Kang1, Jia-Yuan Wu1, Yu Yang2, Hao Wu1, Bin Zhao1, Zhou Liu1, *   

  1. 1Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China; 2Department of Geriatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
  • Online:2022-03-15 Published:2021-10-15
  • Contact: Zhou Liu, MD, liuzhou@gdmu.edu.cn.
  • Supported by:
    This study was supported by a grant from the Clinical Research Project of Affiliated Hospital of Guangdong Medical University of China, Nos. LCYJ2018A00 (to ZL) and LCYJ2019C006 (to YSC); the Natural Science Foundation of Guangdong Province of China, No. 2020A151501284 (to ZL); the Science and Technology Planning Project of Zhanjiang of China, No. 2018A01021 (to ZL); and a grant from the Characteristic Innovation Projects of Colleges and Universities in Guangdong Province of China, No. 2019KTSCX045 (to ZL).

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摘要：

日常生活活动能力受限是否会增加老年人脑卒中的风险，目前尚存在争议。此次纵向研究使用了中国老年健康影响因素跟踪调查（CLHLS）的数据，分析日常生活活动能力受限对老年人脑卒中发生率的影响。试验纳入了2002至2011年间，中国22个省级行政单位的46728名参与者，其中11241名为日常生活活动能力受限者，并随访3年以确定脑卒中的发生情况。（1）结果显示在3年的随访中，日常生活活动能力受限组和未受限组分别有929名（8.26%）和2434名（6.86%）发生脑卒中；（2）以Logistic回归分析日常生活活动能力受限对脑卒中风险的影响。结果显示与无日常生活活动能力受限者相比在调整了性别、年龄、体质量、高血压、糖尿病、心脏病、天然牙齿、听力障碍、视力障碍、吸烟、喝酒、运动、识字、种族和贫穷后，日常生活活动能力受限者发生脑卒中的风险提高了77%；（3）倾向评分匹配平衡基线特征后，风险增加仍高达33％（OR = 1.326，95％CI 1.174-1.497）；（4）结果确定了日常生活活动能力受限是脑卒中的危险因素。

https://orcid.org/0000-0002-5698-3945 (Zhou Liu)

关键词: 日常生活活动能力, 脑卒中, 风险, 队列研究, 中国老年健康影响因素跟踪调查, 调查, 中国老年人, 倾向评分匹配

Abstract: It remains unclear whether limitations in activities of daily living (ADL) increase the risk of stroke in older Chinese adults. This longitudinal study used data from the Chinese Longitudinal Healthy Longevity Survey to investigate the effects of limitations in ADL on the incidence of stroke in older adults. Between 2002 and 2011, 46,728 participants from 22 provinces in China were included in this study. Of participants, 11,241 developed limitations in ADL at baseline. A 3-year follow-up was performed to determine the incidence of stroke. During the 3-year follow-up, 929 participants (8.26%) and 2434 participants (6.86%) experienced stroke in the ADL limitations group and non-ADL limitations group, respectively. Logistic regression was used to analyze the effect of ADL limitations on the risk of stroke. The results showed that after adjusting for the confounding factors gender, age, weight, hypertension, diabetes, heart disease, natural teeth, hearing impairment, visual impairment, smoking, alcohol abuse, exercise, ethnicity, literacy, residential area, and poverty, the ADL limitations group had a 77% higher risk of developing stroke than the non-ADL limitations group. After propensity score matching, the ADL limitations group still had a 33% higher risk of developing stroke than the non-ADL limitations group (OR = 1.326, 95% CI: 1.174–1.497). These findings suggest that limitations in ADL are a stroke risk factor.

Key words: activities of daily living, Chinese Longitudinal Healthy Longevity Survey, cohort, older Chinese individuals, propensity score matching, risk, stroke, survey

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