中国神经再生研究(英文版) ›› 2026, Vol. 21 ›› Issue (2): 636-647.doi: 10.4103/NRR.NRR-D-24-00963

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

非编码RNAs在脑积水中的生理和病理功能

  

  • 出版日期:2026-02-15 发布日期:2025-05-22

Novel insights into non-coding RNAs and their role in hydrocephalus

Zhiyue Cui1, 2, 3, 4, #, Jian He5, #, An Li2, 3, 4, Junqiang Wang2, 3, 4, Yijian Yang2, 3, 4, Kaiyue Wang2, 3, 4, Zhikun Liu2, 3, 4, Qian Ouyang2, 3, 4, 6, Zhangjie Su7 , Pingsheng Hu1, *, Gelei Xiao2, 3, 4, *   

  1. 1 Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan Province, China;  2 Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China;  3 Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, Hunan Province, China;  4 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province, China;  5 Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China;  6 Department of Neurosurgery, Zhuzhou Hospital, Central South University Xiangya School of Medicine, Zhuzhou, Hunan Province, China;  7 Department of Neurosurgery, Addenbrooke ’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, UK
  • Online:2026-02-15 Published:2025-05-22
  • Contact: Gelei Xiao, PhD, xiaogelei@csu.edu.cn; Pingsheng Hu, MD, hupingsheng@hnca.org.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82171347, 82371362; the Natural Science Foundation of Hunan Province, No. 2022JJ30971; the Scientific Research Project of Hunan Provincial Health Commission of China, No. 202204040024 (all to GX).

摘要:

非编码RNA(non-coding RNAs, ncRNAs)是一类不编码蛋白质的功能性RNA,它们协调细胞功能,对人类的生长发育有巨大的影响。研究发现,ncRNAs在健康情况下及病理生理条件下通过RNA/蛋白支架、海绵和表观遗传修饰调节细胞过程,从而起到控制转录和翻译的生物学作用。ncRNAs与脑积水及相关疾病的关系这一主题在近五年有了新的进展,然而,这个主题还有待更新和总结。此综述首先总结了最近脑积水和ncRNA的基本理论。在然后,重点讨论了ncRNAs参与脑积水发生发展的病理生理机制,如:ncRNAs参与中枢神经系统及脉络丛发育缺陷、神经炎症、类淋巴系统等。了解ncRNAs的功能将有助于制定治疗脑积水的潜在诊断、预后和治疗策略。

https://orcid.org/0000-0001-9234-0595 (Gelei Xiao)

关键词: 脑积水, 非编码, RNA, 神经发育, 神经炎症, 治疗目标

Abstract: A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation. This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus, one of the most common neurological conditions worldwide. In this review, we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition. Then, we outline the definition, classification, and biological role of non-coding RNAs. Subsequently, we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail. Specifically, we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus, including glymphatic pathways, neuroinflammatory processes, and neurological dysplasia, on the basis of the existing evidence. Lastly, we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.

Key words: hydrocephalus, neurodevelopment, neuroinflammation, non-coding RNA, therapeutic target