中国神经再生研究(英文版) ›› 2021, Vol. 21 ›› Issue (5): 1910-1925.doi: 10.4103/NRR.NRR-D-24-01191

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

光声技术在神经系统疾病中的应用:一种新兴的神经调控策略

  

  • 出版日期:2026-05-15 发布日期:2025-08-21

Photoacoustic technologies in nervous system disorders: An emerging strategy for neuromodulation

Chenyuan Ding1, 2, #, Penghao Liu1, 2, #, Zhuofan Xu1, 2, Yuanchen Cheng1, 2, Han Yu3, 4, Lei Cheng1, 2, Zan Chen1, 2, Fengzeng Jian1, 2, *, Wanru Duan1, 2, *   

  1. 1 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China;  2 Laboratory of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHNA-INI), Beijing, China;  3 Department of Chemistry, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, Energy Institute and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration & Reconstruction, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region, China;  4 Hong Kong University of Science and Technology-Shenzhen Research Institute, Shenzhen, Guangdong Province, China
  • Online:2026-05-15 Published:2025-08-21
  • Contact: Wanru Duan, MD, duanwanru@xwhosp.org; Fengzeng Jian, MD, jianfengzeng@xwh.ccmu.edu.cn.
  • Supported by:
    This work was supported by the National Key R&D Program of China, No. 2023YFC2509700; the Beijing Natural Science Foundation-Haidian Original Innovation Joint Fund, No. L232141; and the Research and Application of Clinical Characteristic Diagnosis and Treatment Program, No. Z221100007422019 (all to WD).

摘要:

神经系统疾病,尤其是脊髓损伤是一种破坏性疾病,目前的方法往往无法恢复神经功能。通过电信号进行脊髓刺激已成为一种治疗脊髓损伤的有前途的方法。基于类似的原理,此综述探讨了光学和声学技术在神经调控中的可能性,并强调了它们在脊髓损伤方面的优势。光声成像因其无创伤性、高分辨率能力和成本效益而闻名,在早期诊断、动态监测以及作为干细胞手术治疗脊髓损伤的指导工具方面发挥着重要作用,因而备受关注。此外,光声动力学疗法为组织再生提供了多种途径。光遗传学和声遗传学利用基因工程技术,能够更精确地激活神经细胞。光声电疗法利用光伏材料对神经系统进行电调控,为神经系统疾病的治疗引入了一种创新模式。这些进展结合在一起,标志着诊断和治疗的变革性转变,有望显著增强神经功能重塑,改善患者预后。

https://orcid.org/0000-0003-4751-3666 (Wanru Duan); https://orcid.org/0000-0001-7860-278X (Fengzeng Jian)

关键词: 神经调控, 光遗传学, 光声成像, 光声动力学疗法, 脊髓损伤

Abstract: Spinal cord injury is a severe neurological disorder; however, current treatment methods often fail to restore nerve function effectively. Spinal cord stimulation via electrical signals is a promising therapeutic modality for spinal cord injury. Based on similar principles, this review aims to explore the potential of optical and acoustic neuromodulation techniques, emphasizing their benefits in the context of spinal cord injury. Photoacoustic imaging, renowned for its noninvasive nature, high-resolution capabilities, and cost-effectiveness, is well recognized for its role in early diagnosis, dynamic monitoring, and surgical guidance in stem cell therapies for spinal cord injury. Moreover, photoacoustodynamic therapy offers multiple pathways for tissue regeneration. Optogenetics and sonogenetics use genetic engineering to achieve precise neuronal activation, while photoacoustoelectric therapy leverages photovoltaic materials for electrical modulation of the nervous system, introducing an innovative paradigm for nerve system disorder management. Collectively, these advancements represent a transformative shift in the diagnosis and treatment of spinal cord injury, with the potential to significantly enhance nerve function remodeling and improve patient outcomes.

Key words: neuromodulation, optogenetics, photoacoustic imaging, photoacoustodynamic therapy, spinal cord injury